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Autopsy case of acute liver failure due to scrub typhus |
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| Authors: | Yoshihiro Shioi Akihiko Murakami Yasuhiro Takikawa Yoshiharu Miyate Nobukazu Tomichi Kazuo Takayama Noriyuki Uesugi Tamotsu Sugai |
| Affiliation: | (1) Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan;(2) Department of Endoscopy, Iwate Prefectural Central Hospital, 1-4-1 Ueda, Morioka 020-0066, Japan;(3) Department of Gastroenterology and Hepatology, School of Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan;(4) Department of Intensive Care Unit, Iwate Prefectural Central Hospital, 1-4-1 Ueda, Morioka 020-0066, Japan;(5) Department of Pathology, Iwate Prefectural Central Hospital, 1-4-1 Ueda, Morioka 020-0066, Japan |
| Abstract: | Scrub typhus (Tsutsugamushi disease) is an acute febrile disease caused by infection with Orientia tsutsugamushi transmitted by mites. Although patients with scrub typhus commonly display mild liver injury, few die of acute liver failure. We describe herein an autopsy case of acute liver failure due to scrub typhus, which was complicated by disseminated intravascular coagulation and showed rapid progression of liver injury just before death. Histopathological findings revealed submassive hepatocellular necrosis, inflammatory cell infiltration in Glisson’s capsules, and sporadic fibrin thrombi in the hepatic sinusoids. Cause of death was primarily associated with acute liver failure related to disseminated intravascular coagulation. |
| Keywords: | Scrub typhus (Tsutsugamushi disease) Acute liver failure Massive hepatic necrosis Disseminated intravascular coagulation (DIC) |
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