轮状病毒肠炎患儿血清可溶性白细胞介素-2受体白细胞介素-10水平的变化和干扰素的调节作用

目的:探讨IL-10、SIL-2R在轮状病毒肠炎发病和恢复中的临床意义.方法:将轮状病毒肠炎患儿40例分为干扰素组和非干扰素组,测定两组患儿急性期和恢复期 IL-10 和SIL-2R 水平并与正常对照组比较.结果:急性期两组IL-10 较正常对照组明显下降,有显著性差异(P＜0.01) ;两组SIL-2R较正常对照组升高,有显著性差异(P＜0.01) ;恢复期干扰素组SIL-2R、 IL-10均较非干扰素组高,有显著性差异(P＜0.01).结论:轮状病毒肠炎时SIL-2R增高显示细胞免疫功能受抑,IL-10呈低水平状态显示机体免疫失衡,干扰素增强细胞免疫功能并纠正免疫失衡,促进轮状病毒肠炎恢复.

Changes and Regulation Effects of the Serums Level of IL-10 and SIL-2R at the Children Patient with Rotavirus Enteritis

Objective: To explore the clinical meaning about the level of interleukin-10(IL-10) and soluble interleukin-2 receptor(SIL-2R) at the children patient with rotavirus enteritis during the acute stage and the recovery phase.Method: Divided the 40 patients into two groups,interferon group and non-interferon group,determinate their serums level of IL-10 and SIL-2R at acute stage and recovery phase,and compare with the normal control.Result: At acute stage,compare the interferon group and the non-interferon group with the normal control,we find the levels of IL-10are evidently drop,the levels of SIL-2R are raising,and the difference is marked(p<0.01).At recovery phase,compare the interferon group with the non-interferon group,we find the levels of SIL-2R,IL-10are raising and the difference is marked(p<0.01).Conclusion: At the patient of rotavirus enteritis,the raising SIL-2R level reveals the cellular immune function was restrained.The low level of IL-10 reveals the immunity was imbalance.Interferon can accentuate the cellular immune function and correct the immunity unbalance,and facilitate the rotavirus enteritis to recover.