香椿叶水提物对小鼠炎症抑制作用

目的 研究香椿叶水提物抗炎作用机制。方法 观察香椿叶水提物对二甲苯所致小鼠耳廓肿胀、角叉菜胶所致大鼠足肿胀、炎症组织和血清中前列腺素E₂(PGE₂)、一氧化氮(NO)含量的影响。结果 0.5,1.5 g/kg香椿叶水提物灌胃给药能明显抑制对二甲苯所致小鼠耳廓肿胀,抑制率分别为33.85%和46.98%;对照组大鼠注射角叉菜胶2,4 h后,足跖肿胀度为(0.68±0.19),(1.12±0.10)mL,6 h时开始恢复;对角叉菜胶所致正常大鼠足肿胀,香椿叶水提物高、低剂量组注射3和2 h后与对照组比较可明显抑制;低、高剂量香椿叶水提物可降低肿胀足爪组织中NO及PG E₂含量;低剂量香椿叶水提物可降低血清中NO含量。结论 香椿叶水提物可能通过影响炎症介质释放和减少NO的生成而起到抑制角叉菜胶性大鼠足肿胀作用。

Anti-inflammation effect and its mechanism of aqueous extract from Toona sinensis

Objective To study the anti-inflammatory effect of aqueous extract from Toona sinensis and its mechanism.Methods The contents of prostaglandin E2(PGE2) and nitric oxide(NO) in serum and tissue were detected in rats with xylene-induced ear edema and carrageenin-induced paw edema and treated with gastric gavage of aqueous extract form Toona sinensis.Results Aqueous extract from Toona sinensis showed a marked suppressive efffect on xylene-induced ear edema of rats with the inhibition rates of 33.85% and 46.98%...