| 基于BP神经网络的半夏泻心汤及其类方性味药组对小鼠小肠运动的影响 |
| |
| 引用本文： | 杨学智,郭宙,司银楚,李海燕,杜红,朱庆文,宋小莉,高艳青,刘晓霓,牛欣,宋一伦.基于BP神经网络的半夏泻心汤及其类方性味药组对小鼠小肠运动的影响[J].中华中医药杂志,2009(7). |
| |
| 作者姓名： | 杨学智 郭宙 司银楚 李海燕 杜红 朱庆文 宋小莉 高艳青 刘晓霓 牛欣 宋一伦 |
| |
| 作者单位： | 北京中医药大学;山东中医药大学;首都医科大学附属佑安医院;牡丹江医学院; |
| |
| 基金项目： | 国家自然科学基金资助项目(No.30672736); 国家中西医结合基础重点学科211工程资助项目(No.2000-004) |
| |
| 摘 要： | 目的:探讨半夏泻心汤及其类方中性味药组对小鼠小肠运动的影响。方法:采用均匀设计法对半夏泻心汤及其类方进行拆方,测定各配比组合对正常对照、小肠运动抑制模型、小肠运动亢进模型小鼠小肠推进率的影响;基于BP神经网络,针对实验数据建立药味与药效指标的非线性映射模型;在模型基础上,固定各药组中药物的用量比例,进而分别筛选各药组在全方背景下的量效关系。结果:在半夏泻心汤及其2个类方中,半夏和干姜对小鼠肠运动抑制及亢进模型具有双向调节作用;干姜对正常小鼠的肠运动有明显的促进作用,半夏的作用不明显。结论:在肠运动模型,半夏的药效学作用与半夏泻心汤具有高度的一致性,提示半夏可能为半夏泻心汤之君药;但仅从小肠推进率的药效作用,尚难归纳出生姜和甘草的配伍角色。
|
| 关 键 词： | 半夏泻心汤 类方 BP神经网络 小肠运动 |
Investigation of the effects on small intestine motility of different ingredient groups in Banxiaxiexin recipe and Banxiaxiexin-allied recipes by using the BP neural network technique |
| |
| YANG Xue-zhi,GUO Zhou,SI Yin-chu,LI Hai-yan,DU Hong,ZHU Qing-wen,SONG Xiao-li,GAO Yan-qing,LIU Xiao-ni,NIU Xin,SONG Yi-lun.Investigation of the effects on small intestine motility of different ingredient groups in Banxiaxiexin recipe and Banxiaxiexin-allied recipes by using the BP neural network technique[J].China Journal of Traditional Chinese Medicine and Pharmacy,2009(7). |
| |
| Authors: | YANG Xue-zhi GUO Zhou SI Yin-chu LI Hai-yan DU Hong ZHU Qing-wen SONG Xiao-li GAO Yan-qing LIU Xiao-ni NIU Xin SONG Yi-lun |
| |
| Institution: | YANG Xue-zhi1,GUO Zhou1,SI Yin-chu1,LI Hai-yan1,DU Hong1,ZHU Qing-wen1,SONG Xiao-li2,GAO Yan-qing3,LIU Xiao-ni4,NIU Xin1,SONG Yi-lun1(1Beijing University of Chinese Medicine,Beijing 100029,China,2 Sh,ong University of Traditional Chinese Medicine,Jinan 250014,3 Beijing You'an Hospital Affi liated to Capital Medical University,Beijing 100054,4 Mudanjiang Medical College,Mudanjiang 157011,China) |
| |
| Abstract: | Objective:To investigate the effects of the ingredient groups with different pharmacological features in Banxiaxiexin recipe and Banxiaxiexin-allied recipes on small intestine motility.Method:The homogeneous design method was adopted to classify the ingredients of Banxiaxiexin recipe and Banxiaxiexin-allied recipes.The effects of different ingredient matching and combinations on the impelling ratio of the small intestine were observed in the model mice in the normal control group,intestinal motility inhibit... |
| |
| Keywords: | Banxiaxiexin recipe Allied recipe BP neural network technique Small intestine motility |
| 本文献已被 CNKI 等数据库收录！ |
|
