肝病患者血清总胆汁酸和前白蛋白检测的临床价值

目的探讨血清总胆汁酸（TBA）和前白蛋白（PA）监测在肝胆疾病诊断中的临床意义。方法肝病患者42例及对照组32例,均采集清晨空腹静脉血,采用BS-820全自动生化分析仪测定TBA、PA、血清丙氨酸氨基转换酶（ALT）及白蛋白（Alb）。结果重型肝炎、慢性肝炎、肝硬化、肝癌患者血清PA较对照组显著降低（P〈0.01）,血清TBA较对照组显著升高（P〈0.01）。且血清TBA、PA阳性率远高于Alb阳性率（P〈0.01）,肝硬化患者中血清PA和TBA阳性率远高于ALT阳性率（P〈0.01）。结论血清TBA、PA和肝功酶类及合成代谢产物联合检测可大大提高肝胆疾病的检出率。

Clinical value of detection of serum total bile acid and prealbumin in hepatic diseases

Objective To investigate serum total bile acid (TBA) and prealbumin (PA) monitoring in the diagnosis of hepatobiliary disease significance. Methods Patients with liver disease in 42 cases and 32 cases of the control group, all collected fasting venous blood, using BS-820 automatic biochemical analyzer for the determination of TBA, PA, ALT and Alb. Results Severe hepatitis, chronic hepatitis, cirrhosis, hepatocellular carcinoma in patients with serum PA were significantly lower (P < 0.01), serum TBA were significantly increased (P < 0.01).And the serum TBA, PA positive rate is far higher than the positive rate of Alb (P < 0.01) in patients with liver cirrhosis, serum PA and TBA positive rate are far higher than the positive rate of ALT (P < 0.01). Conclusion The serum TBA,PA and liver enzymes and the synthesis of metabolites of joint detection can greatly improve the detection rate of hepatobiliary diseases.