中链脂肪酸对高甘油三酯血症合并不同水平HDL-C患者体重和体脂的影响

目的 探讨中链脂肪酸食用油对高甘油三酯血症合并不同水平高密度脂蛋白胆固醇(HDL-C)患者体重和体脂的影响.方法 将112例高甘油三酯血症患者随机分为中长链脂肪酸(MLCT)食用油组和长链脂肪酸(LCT)食用油组,并指导每日运动量、能量和食用油摄入量(25-30g/d),分别在研究开始及8周后进行人体测量、人体成分分析、腹部脐水平CT扫描测定,组内以HDL-C水平(＜1.04mmol/L、1.1-1.55mmol/L、≥1.55mmol/L)分为三层,比较上述指标差异.结果8周后MLCT组(不同HDL-C水平)与研究前比较均能够显著降低体重和体脂(P＜0.05),而LCT组(不同HDL-C水平)无统计学差异；8周后MLCT组与LCT组相比:HDL-C＜1.04mmol/L患者除腹部脂肪面积差值P＜0.05,其他指标无统计学意义；HDL-C 1.04-1.54mmol/L患者体重差值、BMI差值、腹部脂肪面积差值均P＜0.05,其他指标无统计学意义；HDL-C≥1.55mmol/L者体重差值、BMI差值、腰围差值、腰臀比差值、体内脂肪重差值、体内脂肪百分比差值、腹部脂肪面积差值、腹腔内脂肪面积差值均P＜0.05.结论 合理食用MLCT食用油可以降低高甘油三酯血症合并不同水平HDL-C患者的体重和体脂,其中HDL-C水平正常或较高的高甘油三酯血症患者体重和体脂降低程度更明显.

Effect of medium-chain fatty acid on body weight and body fat in patients with hypertriglyceridemia complicated with different HDL-C levels

Objective To study the effect of medium-chain fatty acid(MCFA) on body weight and body fat in patients with hypertriglyceridemia complicated with different HDL-C levels.Methods One hundred and twelve patients with hypertriglyceridemia were randomly divided into MCFA triacylglycerol(MLFAT) group and long-chain fatty acid triacylglycerol(LCFAT) group.They were asked to ingest fixed energy,25-30g oil and perform physical activity daily during the whole study.Anthropometric measurement,body composition analysis,abdominal CT scanning at umbilical level,and measurement of serum HDL-C levels(<1.04mmol/L,1.1-1.55mmol/L,≥1.55mmol/L) were performed at the beginning and 8 weeks of the study and compared.Results The body weight and body fat were significantly lower in MLFAT group(P<0.05) while no significant difference was observed in body weight and body fat of LCFAT group 8 weeks after treatment than before treatment.No significant difference was found in the other indications except the abdominal fat area in those with HDL-C level<1.04mmol/L(P<0.05) between the two groups 8 weeks after treatment.The body weight,BMI and abdominal fat area were significantly lower in those with HDL-C level =1.04-1.5mmol/L than in LCT group 8 weeks after treatment(P<0.05).The body weight,BMI,waistline,waist-to-hip ratio,body fat,abdominal fat area were significantly lower in those with HDL-C level≥1.5mmol/L than in LCT group 8 weeks after treatment(P<0.05).Conclusion Rational intake of medium-and long-chain fatty acid triacylglycerol can reduce the body weight and body fat in patients with hypertriglyceridemia complicated with different HDL-C levels,especially in those with no normal HDL or HDL-C≥1.04mmol/L.