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| 血浆钙离子浓度对血小板聚集的影响 | |
| 引用本文： | 李祖兰,张立文,丛玉隆,白洁,马长生,邓新立,陈兴明,杨亮程,张杰,刘波. 血浆钙离子浓度对血小板聚集的影响[J]. 军医进修学院学报, 2012, 33(3): 231-232 |
| 作者姓名： | 李祖兰 张立文 丛玉隆 白洁 马长生 邓新立 陈兴明 杨亮程 张杰 刘波 |
| 作者单位： | 1. 总装亚运村门诊部,北京,100101 2. 解放军总医院临检科,北京,100853 3. 解放军第306医院检验科,北京,100101 4. 总装备部黄寺门诊部,北京,100101 |
| 摘 要： | 目的 探讨血浆钙离子浓度对血小板聚集检验结果的影响.方法 采集健康志愿者静脉血标本(n=42),添加不同量的氯化钙,采用血浆比浊法进行血小板聚集率检测.结果 血浆Ca2+浓度在2.1-0.12mmol/l时,二磷酸腺苷(ADP)和花生四烯酸(AA)诱导的血小板聚集率分别为(75.9±10.4)％-(51.8±9.6)％和(83.7±13.9)％-(64.4±12.2)％,血小板聚集率随Ca2+浓度的降低而降低；血浆Ca2+浓度在2.1-33.66mmol/L时,ADP和AA诱导的血小板聚集率分别为(75.9±10.4)％-(94.7士4.8)％和(83.7士13.9)％-(93.2±5.5)％,随Ca2+浓度的增高而增高；Ca2+浓度为39.00mml/L时,血小板聚集率明显降低[ADP和AA诱导的血小板聚集率分别为(9.1±5.3)％和(11.1±4.5)％,均P＜0.01].结论 钙离子浓度波动对血小板聚集检验结果有明显影响.低于生理钙浓度(2.1mmol/L血小板聚集率随Ca2+浓度的降低而降低,高于生理钙浓度血小板聚集率随Ca2+浓度的增高而增高；血钙过高(≥39.0mmol/L)抑制血小板聚集. |
| 关 键 词： | 血小板 血小板聚集 钙 |
Effect of plasma calcium concentration on aggregation of platelets |
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| LI Zu-lan , ZHANG Li-wen , CONG Yu-long , BAI Jie , MA Chang-sheng , DENG Xin-li , CHEN Xing-ming , YANG Liang-cheng , ZHANG Jie , LIU Bo. Effect of plasma calcium concentration on aggregation of platelets[J]. Academic Journal of Pla Postgraduate Medical School, 2012, 33(3): 231-232 | |
| Authors: | LI Zu-lan ZHANG Li-wen CONG Yu-long BAI Jie MA Chang-sheng DENG Xin-li CHEN Xing-ming YANG Liang-cheng ZHANG Jie LIU Bo |
| Affiliation: | 1Yayuncun Clinic of General Equipment Department,Beijing 100101,China;2Clinical Laboratory,Chinese PLA General Hospital,Beijing 100853,China;3Clinical Laboratory,Chinese PLA 306 Hospital,Beijing 100101,China;4Huangsi Clinic of General Equipment Department,Beijing 100101,China |
| Abstract: | Objective To study the effect of plasma calcium concentration on aggregation of platelets.Methods Different amounts of CaCl2 were added into venous blood samples taken from healthy volunteers(n=42).Aggregation of platelets was detected by plasma turbidimetry.Results when the plasma calcium concentration was 2.11-0.12mmol/L,the aggregation rate of platelets induced by adenosine diphosphate(ADP) and arachidonic acid(AA) was(75.9±10.4)%-(51.8±9.6)% and(83.7±13.9)%-(64.4±12.2)%,respectively(P<0.01),and then decreased with the decreasing concentration of Ca2+.When the plasma calcium concentration was 2.11-33.66mmol/ L,the aggregation rate of platelets induced by ADP and AA was(75.9±10.4)%-(94.7±4.8)% and(83.7±13.9)%-(93.2±5.5)%,respectively(P<0.01),and then increased with the increasing concentration of Ca2+.When the plasma calcium concentration was 39.00 mmol/ L,the aggregation rate of platelets induced by ADP and AA was 9.1%±5.3% and 11.1%±4.5%,respectively(P<0.01).Conclusion Plasma calcium concentration has a significant effect on aggregation of platelets.When the physiological concentration of Ca2+ is lower than 2.1mmol/L,the aggregation rate of platelets decreases with the decreasing concentration of Ca2+.When the physiological concentration of Ca2+ is higher than 2.1mmol/L,the aggregation rate of platelets increases with the increasing concentration of Ca2+.The aggregation of platelets is inhibited when the plasma calcium concentration is≥39.0 mmol/L. |
| Keywords: | blood platelets platelets aggregation calcium |
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