阿斯匹林对2型糖尿病血清C-反应蛋白及糖尿病肾病发生的影响

目的探讨阿斯匹林对2型糖尿病(T2DM)患者血清超敏C-反应蛋白(hs-CRP)的影响与糖尿病肾病发生的关系.方法107例T2DM患者随机分为:A组48例口服阿斯匹林100mg/晚;B组59例维持原抗糖尿病治疗方案.经过12个月治疗后观察患者血清hs-CRP、尿白蛋白排泄率(UAER)、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(INS)、空腹C肽、甘油三脂(TG)、胆固醇(TC)等指标的变化.结果两组比较,FBG、HbA1c、INS、C肽、TG、TC差异无统计学意义(P>0.05);A组治疗后与治疗前比较,hs-CRP降低(P<0.05),UAER升高,但P>0.05;B组治疗后较治疗前hs-CRP、UAER升高(P<0.01).B组较A组hs-CRP、UAER升高(P<0.01).结论阿斯匹林可以降低T2DM患者血清hs-CRP,对糖尿病肾病的发生有一定的预防和预测作用.

Effect of aspirin on C-reactive protein and diabetic nephropathy in type 2 diabetes mellitus patients

Objective To study the effect of aspirin on serum high sensitive C-reactive protein(hs-CRP)in type 2 diabetes mellitus(T2DM) patients and its relation with diabetic nephropathy.Methods One hundred and seven T2DM patients were randomly divide into group A(n=48) and group B(n=59).Patients in group A took 100mg aspirin per os/night and those in group B received routine anti-diabetic therapy for 12 months,then serum levels of hs-CRP,urinary albumin excretion rate(UAER),fast blood glucose(FBG),glycosylated hemoglobin(HbA1c),fasting insulin(INS),fasting C peptide,triglyceride(TG) and total cholesterol(TC) were measured.Results No significant difference was found in serum levels of FBG,HbA1c,INS,fasting C peptide,TG and TC between the two groups(P>0.05).The serum hs-CRP level was lower while the serum UAER level was higher in group A after treatment than before treatment(P<0.05).The serum hs-CRP and UAER levels were higher in group B after treatment than before treatment(P<0.01).The serum hs-CRP and UAER levels were higher in group B than in group A(P<0.01).Conclusion Aspirin can reduce the serum hs-CRP level in T2DM patients and plays a certain role in prevention and prediction of diabetic nephropathy.