血清高迁移率族蛋白1水平与皮肌炎/多肌炎的关系

目的 检测皮肌炎/ 多肌炎(PM/DM) 患者血清中高迁移率族蛋白1(high mobility group box chromosomal protein 1,HMGB1) 的水平,探讨其在PM/DM 中的发病机制及诊断价值.方法 选取47 例明确诊断PM/DM 的患者,41 例系统性红斑狼疮(SLE) 患者,及其他风湿免疫性疾病患者37 例,同时选取健康志愿者50 例,采用ELISA 方法检测各组血清中HMGB1水平,分析其与PM/DM 及其他风湿免疫性疾病的相关性.结果 血清HMGB1 在PM/DM 及SLE 患者中水平明显高于健康对照组(分别为22.65ng/ml、16.76ng/ml 及7.24ng/ml)(P<0.01),在PM/DM 患者中的表达明显高于SLE 及其他风湿免疫性疾病组(分别为22.65ng/ml、16.76ng/ml 及12.39ng/ml)(P<0.05),Logistic 回归分析显示,HMGB1 与PM/DM 具有显著相关性.结论 PM/DM 患者血清HMGB1 水平明显升高,提示HMGB1 可能作为促炎因子在PM/DM 的发病中起重要作用,HMGB1或可做为诊断PM/DM 的辅助检查之一.

Correlation between serum high mobility group box chromosomal protein 1 level and dermatomyositis/polymyositis

Objective To study the value of high mobility group box chromosomal protein 1(HMGB1) for diagnosis of polymyositis/dermatomyositis(PM/DM) by measuring its serum level in patients with PM/DM.Methods Forty-seven PM/DM patients,41 patients with SLE,37 patients with other rheumatic diseases and 50 healthy volunteers were enrolled in this study.Their HMGB1 level was measured by ELISA and correlation between HMGB1 level and other rheumatic diseases was analyzed.Results The serum HMGB1 level was significantly higher in patients with PM/DM and SLE than in healthy volunteers(22.65pg/ml vs 16.76pg/ml and 7.24pg/ml, P<0.01),and in patients with PM/DM than in those with SLE and other rheumatic diseases(22.65ng/ml vs 16.76ng/ml and 12.39ng/ml, P<0.05).Logistic regression analysis showed that the serum HMGB1 level was correlated with PM/DM.Conclusion The serum HMGB1 level is significantly higher in patients with PM/DM than in those with other rheumatic diseases,indicating that HMGB1 may play an important role in the pathogenesis of PM/DM and can therefore be used as a diagnostic marker of PM/DM.