肺癌脑膜转移10例临床分析

目的 探讨肺癌脑膜转移的临床诊断、治疗和预后.方法 收集本院2006-2011年间肺癌脑膜转移患者10 例,结合文献对其临床特点、诊断方法、治疗及预后进行回顾性分析.结果 10 例肺原发病变均有明确病理组织学分类,脑膜转移病变均有影像学诊断依据,其中2 例脑脊液(CFS) 中找到癌细胞,5 例单独应用靶向药物治疗,2 例靶向药物+ 全脑放疗,单独鞘内化疗、鞘内化疗+ 靶向药物及鞘内化疗+ 全脑放疗+ 靶向药物治疗者各1 例.总生存期4 周-24 个月,中位生存期8 个月.结论 脑膜转移是肺癌的危重并发症之一,死亡率较高,如能及早诊断并及时给予综合治疗能明显延长患者生存期,改善预后.

Meningeal metastasis of lung cancer: A clinical analysis of 10 cases

Objective To study the clinical diagnosis,treatment and prognosis of patients with meningeal metastasis of lung cancer.Methods Clinical diagnosis,treatment and prognosis of 10 patients with meningeal metastasis of lung cancer admitted to our hospital from 2006 to 2011 were retrospectively analyzed.Results Primary lung cancer in 10 cases was confirmed by pathology and meningeal metastasis of lung cancer was diagnosed by MRI.Among these patients,cancer cells were found in cerebrospinal fluid(CSF) of 2 patients,5 were treated with targeted drugs alone,2 were treated with targeted drugs plus whole cerebral radiotherapy,1 was treated with intrathecal chemotherapy,intrathecal radiotherapy and targeted drugs,1 was treated with intrathecal chemotherapy,whole cerebral radiotherapy and targeted drugs.The total survival time of patients was 4weeks-24 months and the median survival time of patients was 8 months.Conclusion Meningeal metastasis is one of the most critical complications of lung cancer with a rather high mortality.Its early diagnosis and treatment can prolong survival time of such patients and improve their prognosis.