贝那普利联合乐卡地平治疗轻中度高血压的近期疗效和安全性

目的 观察贝那普利联合乐卡地平治疗轻、中度高血压的近期疗效及安全性.方法 采用随机、单盲、对照方法,将轻中度高血压患者101 例随机分为A 组(贝那普利10mg+ 乐卡地平10mg) 和B 组(贝那普利10mg),服药4 周后坐位舒张压≥ 90mmHg(1mmHg=0.133kPa) 的患者贝那普利服用剂量加倍,共治疗8 周,评价治疗1、4、8 周末患者降压幅度、疗效及不良反应.结果 治疗1、4、8 周末,两组坐位血压较治疗前均有下降,8 周末收缩压/ 舒张压A 组为(133.72±11.87)mmHg/(80.11±8.77)mmHg,B 组为(142.04±12.34)mmHg/(87.56±9.88)mmHg(P<0.05),降压总有效率A 组为89.1%,B 组为67.0%(P<0.05).2 组不良事件发生率差异无统计学意义(P>0.05).结论 贝那普利联用乐卡地平片可增加降压作用并提高疗效,且无明显不良反应.

Short-term therapeutic effect and safety of combined benazepril and lercanidipine for mildmoderate hypertension

Objective To observe the short-term therapeutic effect and safety of combined benazepril and lercanidipine for mild-moderate hypertension.Methods One hundred and one patients with mild-moderate hypertension were randomly divided into group A and group B.Four weeks after patients in group A were treated with combined benazepril(10mg/d) and lercanidipine(10mg/d) and those in group B were treated with benazepril(10mg/d) alone,benazepril was increased to 20mg/d for those with their DBP at sitting≥90mmHg for 8 weeks.Then,their blood pressure reduction,curative effect and adverse reaction were assessed 1,4 and 8 weeks after treatment with combined benazepril and lercanidipine.Results The DBP in two groups at sitting was lower after 1,4 and 8 weeks of treatment with combined benazepril and lercanidipine than before treatment.The systolic and diastolic pressure at sitting was(133.72±11.87)mmHg and(80.11±8.77)mmHg respectively in group A,and(142.04±12.34)mmHg and(87.56±9.88)mmHg respectively in group B(P<0.05),with a total effective rate of 89.1% in group A and 67.0% in group B after 8 weeks of treatment(P<0.05).No significant difference was observed in adverse reaction between the two groups.Conclusion Combined benazepril and lercanidipine can decrease the blood pressure and increase the therapeutic effect for hypertension with no significant adverse reactions.