肾移植术后带状疱疹的诊断与治疗

目的探讨肾移植术后带状疱疹的发病特点,提高其诊治水平.方法回顾性分析我中心2005年1月-2011年1月18例肾移植术后带状疱疹病例的临床资料,对其诊治进行临床总结和分析.结果18例发病时间为肾移植术后6-27个月,平均16.5个月,其中术后12-24个月发病者为14例,占77.8%.给予减少免疫抑制剂用量,应用抗病毒药物阿昔洛韦治疗10例,更昔洛韦5例,喷昔洛韦3例,同时应用抗感染药物、对症治疗等.所有患者均痊愈.结论带状疱疹在肾移植术后患者体内呈机会性感染,免疫过度可能导致其发生.

Diagnosis and treatment of herpes zoster after renal transplantation

Objective To improve the diagnosis and treatment of herpes zoster by studying its onset features after renal transplantation.Methods Clinical data about 18 patients with herpes zoster after renal transplantation admitted to our center from January 2005 to Janary 2011 were retrospectively analyzed with its clinical diagnosis and treatment summarized.Results The onset time of herpes zoster was 6-27 months in 18 patients after renal transplantation(mean 16.5 months) and was 12-24 months in 14 patients(77.8%) after renal transplantation.The patients were completely cured after treated with dose-reducing immunosuppressive agents and antiviral drug(acyclovir) in 10 patients,ganciclovir in 5 patients and penciclovir in 3 patients.Conclusion Opportunistic infection may occur in patients with herpes zoster after renal transplantation due to over immunosuppressive drug therapy.