首页 | 本学科首页   官方微博 | 高级检索  
     


Genetic study of eight AKT1 gene polymorphisms and their interaction with DRD2 gene polymorphisms in tardive dyskinesia
Authors:Zai Clement C  Romano-Silva Marco A  Hwang Rudi  Zai Gwyneth C  Deluca Vincenzo  Müller Daniel J  King Nicole  Voineskos Aristotle N  Meltzer Herbert Y  Lieberman Jeffrey A  Potkin Steven G  Remington Gary  Kennedy James L
Affiliation:Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Abstract:Tardive dyskinesia (TD) is a motor adverse effect of chronic antipsychotic medication. It has been suggested to involve dopamine neurotransmission system changes. AKT1 acts downstream of the D(2) receptor that is blocked by all antipsychotics to some degree. The AKT1 gene has not been investigated in TD. We examined eight polymorphisms spanning the AKT1 gene and their association with TD in our schizophrenia sample of 193 Caucasians, 76 of which with TD. AKT1 polymorphisms and haplotypes were not significantly associated with TD. However, we detected a significant interaction between rs6275 of DRD2 and rs3730358 of AKT1 (p<1 x 10(-5)).
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号