重度子痫前期患者血清补体因子D、补体C5a的表达及与肾功能和平均动脉压的相关性分析

目的探讨重度子痫前期患者血清补体因子D (CFD)、补体C5a的表达及其与肾功能和平均动脉压的相关性,为临床诊治提供参考依据。方法选取2016年2月-2017年10月在长沙市中医医院接受治疗的重度子痫前期患者62例作为观察组,另选取同期正常单胎足月妊娠孕妇40例作为对照组。比较两组患者血清中尿素氮(BUN)、肌酐(Cr)、尿酸(UA)、胱抑素C (Cys-C)的水平以及肌酐清除率(CCr)、24 h尿蛋白总量、平均动脉压,比较两组患者血清中CFD、补体C5a的水平,采用Pearson相关系数分析重度子痫前期患者血清中CFD、补体C5a的表达与肾功能和平均动脉压的相关性。结果观察组血清中BUN、Cr、UA、Cys-C水平以及24 h尿蛋白总量、平均动脉压均显著高于对照组,CCr显著低于对照组,差异有统计学意义(均P<0. 05);观察组血清中CFD、补体C5a水平显著高于对照组,差异有统计学意义(均P<0. 05);重度子痫前期患者血清中CFD、补体C5a与Cr、UA、Cys-C、24h尿蛋白总量、平均动脉压呈正相关(P<0. 05),与CCr呈负相关(P<0. 05)。结论重度子痫前期患者肾功能明显受损,平均动脉压显著升高,且其血清中CFD、补体C5a水平明显上升,CFD、补体C5a与患者的肾功能和平均动脉压密切相关。

Expressions of serum complement factor D and complement C5a in patients with severe preeclampsia and the relationships with renal function and mean arterial pressure

Objective To explore the expressions of serum complement factor D ( CFD) and complement C5a in patients with severe preeclampsia and the relationships with renal function and mean arterial pressure,provide a reference basis for clinical diagnosis and treatment. Methods Sixty-two patients with severe preeclampsia who were treated in Changsha Hospital of Traditional Chinese Medicine from February 2016 to October 2017 were selected as observation group,and 40 normal singleton full-term pregnant women during the same period were selected as control group. The levels of serum urea nitrogen ( BUN),creatinine ( Cr),uric acid ( UA),Cystatin C ( Cys-C),creatinine clearance rate ( CCr),total amount of 24-hour urine protein,and mean arterial pressure were compared between the two groups,the levels of serum CFD and complement C5a in the two groups were compared,and the correlation between the expressions of serum CFD and complement C5a in patients with severe preeclampsia and renal function,mean arterial pressure were analyzed by Pearson correlation coefficient analysis. Results The levels of serum BUN,Cr,UA,Cys-C,and total amount of 24-hour urine protein,and mean arterial pressure in observation group were statistically significantly higher than those in control group,while CCr in observation group was statistically significantly lower than that in control group ( P<0. 05). The levels of serum CFD and complement C5a in observation group were statistically significantly higher than those in control group ( P<0. 05). The levels of serum CFD and complement C5a in patients with severe preeclampsia were positively correlated with Cr,UA,Cys-C,the total amount of 24-hour urine protein,and mean arterial pressure ( P<0. 05),which was negatively correlated with CCr ( P<0. 05). Conclusion Renal function of patients with severe preeclampsia is significantly impaired, mean arterial pressure increases significantly,the levels of serum CFD and complement C5a increase significantly. CFD and complement C5a are closely related to renal function and mean arterial pressure.