肺癌患者异常糖链糖蛋白与传统肿瘤标志物的相关性分析

目的通过回顾性分析肺癌患者异常糖链糖蛋白(TAP)水平以及传统肿瘤标志物癌胚抗原(CEA)、鳞状细胞癌抗原(SCC)、糖类抗原125(CA125)、神经元特异性烯醇化酶(NSE)和细胞角蛋白19片段(CYFRA21-1)水平，探讨肺癌患者TAP与传统肿瘤标志物之间的相互关系。 方法分别采用凝聚素亲和法及电化学发光免疫分析法检测我院呼吸内科经治的181例肺癌患者TAP和5种血清学肿瘤标志物的水平，对所得TAP与5种血清学肿瘤标志物的数据进行spearman相关性检验分析。 结果肺癌患者TAP与CEA呈正相关(P＝0.016)，而与SCC、CA125、NSE及CYFRA21-1之间没有相关性(P值均>0.05)；亚组分析，腺癌、鳞癌患者的TAP与CEA均呈正相关(P值分别为0.021，0.044)，腺癌、鳞癌、小细胞癌及未分类癌患者的TAP与CA125均呈正相关(P值分别0.046，0.007，0.001，0.006)，而这四类癌的TAP与SCC、NSE和CYFRA21-1之间没有明显相关性(P值均>0.05)。 结论肺癌患者TAP值是CEA、CA125等多种肿瘤异常蛋白水平的综合体现，尤其在肺腺癌患者中与传统肿瘤标志物具有较好的正相关性。

Correlation between tumor abnormal protein and tumor markers in patients with lung cancer

ObjectiveThe levels of tumor abnormal protein (TAP) and tumor markers (CEA, SCC, CA125, NSE and CYFRA21-1) were studied in patients with lung cancer, to explore their correlation between TAP and tumor markers in lung cancer. Methods181 cases of patients with lung cancer were recruited in Department of Respiratory Medicine Tang Du Hospital. TAP was measured by coacervation method. And their CEA, SCC, CA125, NSE and CYFRA21-1 were measured by Electro-Chemiluminescence immunoassay (ECLI). Then the relations between TAP and Tumor Markers were analyzed by spearman correlation test. ResultsThere was a positive correlation between TAP and CEA in lung cancer patients (P=0.016), but no correlation with SCC, CA125, NSE and CYFRA21-1 (P>0.05). And subgroup analysis, there was a positive correlation between TAP and CEA in patients with adenocarcinoma and squamous cell carcinoma (P=0.021, 0.044, respectively), a positive correlation between TAP and CA125 in patients with adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and unclassified cancer (P values were 0.046, 0.007, 0.001, 0.006, respectively). However, there was no significant correlation between TAP and SCC, NSE and CYFRA21-1 in the four types of lung cancer (P>0.05). ConclusionThe TAP value is a comprehensive manifestation of a variety of abnormal tumor proteins, such as CEA and CA125, in lung cancer patients. Especially, there was a good positive correlation between TAP and traditional TM in patients with lung adenocarcinoma.