| miR-15a在眼科疾病中的研究现状及进展 |
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| 引用本文： | 李宇博,王峰,苏颖.miR-15a在眼科疾病中的研究现状及进展[J].国际眼科杂志,2020,20(6):999-1002. |
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| 作者姓名： | 李宇博 王峰 苏颖 |
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| 作者单位： | 157000 中国黑龙江省哈尔滨市,哈尔滨医科大学附属第一医院眼科;157000 中国黑龙江省哈尔滨市,哈尔滨医科大学附属第一医院眼科;157000 中国黑龙江省哈尔滨市,哈尔滨医科大学附属第一医院眼科 |
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| 基金项目： | 国家自然科学基金(No.81470633) |
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| 摘 要： | miRNA-15a(miR-15a)是位于13q14基因上的非编码RNA小分子，随着研究的深入，其对全身各组织器官及细胞的生长、凋亡等调控作用越发被重视，成为现今研究较多的miRNA。本文主要针对miR-15a的作用机制及在眼科疾病中的研究现况进行阐述，为进一步研究眼科疾病及治疗提供可借鉴的参考依据。
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| 关 键 词： | miR-15a 眼科疾病 糖尿病视网膜病变 白内障 视网膜血管内皮细胞 视网膜色素上皮细胞 |
| 收稿时间： | 2018/1/29 0:00:00 |
| 修稿时间： | 2020/4/29 0:00:00 |
Research status and progress of miR-15a in ophthalmological diseases |
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| Yu-Bo Li,Feng Wang and Ying Su.Research status and progress of miR-15a in ophthalmological diseases[J].International Journal of Ophthalmology,2020,20(6):999-1002. |
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| Authors: | Yu-Bo Li Feng Wang and Ying Su |
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| Institution: | Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin 157000, Heilongjiang Province, China,Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin 157000, Heilongjiang Province, China and Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin 157000, Heilongjiang Province, China |
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| Abstract: | miRNA-15a(miR-15a)is a non-coding small molecule RNA located on 13q14 gene. It affects the growth, development, differentiation and apoptosis of all organs and cells of the whole body. As the study progressively deepened, it was found that the role of miR-15a in different tissues and cells was not entirely consistent. Sometimes it plays a role in suppressing cancer, and sometimes it promotes cancer. The signal pathways it affects are complex and diverse. With the deepening of biological research into cell signaling pathways, miRNA-15a has become a miRNA more extensively studied. But in the ophthalmology, the corresponding research is not much. In this article, we mainly focus on the mechanism of miR-15a and its current research situation in ophthalmic diseases, so as to provide a reference for further study and their treatment. |
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| Keywords: | miR-15a ophthalmic diseases diabetic retinopathy cataract retinal vascular endothelial cells retinal pigment endothelial cells |
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