老年冠脉事件患者晨峰血压和高敏C反应蛋白水平变化的相关性

目的 探讨老年冠脉事件患者中晨峰血压(MBPS)和高敏C反应蛋白(hs-CRP)水平变化的关系及临床价值.方法 123例患者,陈旧性心肌梗死组(OMI)55例、陈旧性心肌梗死再发急性冠脉综合征组(OMI+ACS)68例.50例非冠心病者作为对照组.所有对象均排除感染、恶性肿瘤、血液病、瓣膜病、先天性心脏病、主动脉夹层、继发性高血压病、肝肾功能不全.行24 h动态血压监测并计算晨峰血压(MBPS),免疫比浊法测定血清hs-CRP,分析晨峰血压和hs-CRP平变化的关系.结果 OMI组与对照组的hs-CRP和MBPS差异均有统计学意义(0.01＜P＜0.05),其余各组的hs-CRP和MBPS差异均有统计学意义(P＜0.01),老年冠心病患者hs-CRP与晨峰血压(MBPS)水平之间呈正相关(r=0.76,P＜0.01).结论 晨峰血压与机体血管的损伤性炎症反应的关键风险因子hs-CRP密切相关,两者对老年患者的冠脉事件发生发展有重要影响,对评估老年人再发急性冠脉事件有重要临床价值.

Abstract：

Objective To explore the relationship between the level of morning blood pressure surge (MBPS) and High-sensitivity C-reactive protein( hs-CRP) in acute coronary events among old patients and to evaluate their clinical value. Methods One hundred and twenty - three patients with coronary disease were divided into two groups, each of which was old myocardial infarction(OMI, n = 55) and old myocardial infarction with acute cardiovascular syndrome (OMI + ACS, n =68). The control group includes the patients without coronary disease( n =50). The patients who have infection, malignant tumors, liver and kidney dysfunction, blood diseases, valvular heart diseases, congenital heart diseases, aortic dissection,secondary hypertension were not included. All groups were received 24 hours ambulatory blood pressure monitoring to calculate MBPS and the determination of hs-CRP in serum. Results Compared with each two groups, the levels of MBPS and hs-CRP in OMI group were significantly higher than those of the control group (0. 01 ＜ P ＜0. 05) , and had more significance in the other groups ( P ＜0.01). The levels of MBPS and hs-CRP had positive relationship in coronary events in the elderly ( r =0. 76, P ＜0. 01) . Conclusion The level of MBPS is positively correlated with serum hs-CRP which is one of key risk factors of inflammatory reactions by impairing vessels in body. The two factors both play important roles in the occurrence and the development of coronary events among old patients. They both have important clinical value in recurrent acute coronary events among old patients.

Clinical study of the relationship between the level of morning blood pressure surge and hs-CRP in coronary events among old patients

Objective To explore the relationship between the level of morning blood pressure surge (MBPS) and High-sensitivity C-reactive protein( hs-CRP) in acute coronary events among old patients and to evaluate their clinical value. Methods One hundred and twenty - three patients with coronary disease were divided into two groups, each of which was old myocardial infarction(OMI, n = 55) and old myocardial infarction with acute cardiovascular syndrome (OMI + ACS, n =68). The control group includes the patients without coronary disease( n =50). The patients who have infection, malignant tumors, liver and kidney dysfunction, blood diseases, valvular heart diseases, congenital heart diseases, aortic dissection,secondary hypertension were not included. All groups were received 24 hours ambulatory blood pressure monitoring to calculate MBPS and the determination of hs-CRP in serum. Results Compared with each two groups, the levels of MBPS and hs-CRP in OMI group were significantly higher than those of the control group (0. 01 ＜ P ＜0. 05) , and had more significance in the other groups ( P ＜0.01). The levels of MBPS and hs-CRP had positive relationship in coronary events in the elderly ( r =0. 76, P ＜0. 01) . Conclusion The level of MBPS is positively correlated with serum hs-CRP which is one of key risk factors of inflammatory reactions by impairing vessels in body. The two factors both play important roles in the occurrence and the development of coronary events among old patients. They both have important clinical value in recurrent acute coronary events among old patients.