特发性眼睑口下颌痉挛综合征

目的：观察特发性眼睑口下颌痉挛综合征的临床表现和A－型肉毒毒素并联合口服抗痉挛药物的治疗效果。方法：对持续发性眼睑口下凳痉挛综合征进行临床分析，使用A－型肉毒毒素对痉挛肌肉进行多点注射（每点0．1－0．2ml,2.5-5U)，同时服用抗乙酰胆碱和苯二氮Zhuo卓类药物，结果：A－型肉毒毒素为眼睑痉亦的治疗4－5天出现症状缓解，1个星期症状明显缓解，2个星期疗效达最高峰。有效率100％，有效作用时间为10－24周，平均11．7周。而抗乙酰胆碱和苯二氮Zhuo类药物对口下颌肌张力障碍的治疗效果比较明显，可以有效的缓解患者的磨牙嘴和舌不自主伸缩等症状。结论：A－型肉毒毒素和抗乙酰胆碱及苯二氮Zhuo类药物联合应用是治疗特发性眼睑口下颌痉挛综合的一种安全，有效、简便的方法。

Ormandibular Dystonia Syndrome

Objective: To study the clinical characteristic of Ormandibular Dystonia (OMD) Syndrome. To valuate the efficacy of CBTX-A (China botulinum toxin A) was made by Lanzhou Biological products institute in China, Artane and Clonazepam used for treatment OMD Syndrome. Methods: Thirty patients with OMD Syndrome were treated with CBTX-A local injections (2. 5-5 U for each injection) and Artance, Clonazepam tablets. Result: Spasm symptom slight relieved 4- 5 days after treatment and remarkable relieved one week after treatment. All patients experienced relief from spasm symptom. The relieved duration was 10 -24 weeks, (mean 11. 7 weeks). The local side effects were transient and mild, minor ptosis in 20%. Conclusion: The treatment of CBTX-A, Artane and Clonazepam was a safe, effective and simple means for OMD Syndrome.