深圳地区类流感疾病暴发的病因研究

深圳地区于１９９４年３月底至５月中发生了类流感疾病暴发。病原学和血清学研究均证实其病因为乙型流感病毒。抗原性分析指出，分离毒株的抗原性类似于Ｂ／沪防／１／９３和Ｂ／粤防／８／９３毒株（它们为Ｂ／Ｖｉｃｔｏｒｉａ／２／８７类毒株）。基因分析指出，分离毒株的ＨＡ１区基因长度与Ｂ／沪防／１／９３毒株一样为１０３８个核苷酸，编码３４６个氨基酸，它们之间ＨＡ１蛋白分子上氨基酸序列的同源性高达９５．００％以上。这就进一步证实了分离物为Ｂ／Ｖｉｃｔｏｒｉａ／２／８７类毒株。同时也表明了当前在我国人群中同时流行着两种抗原性和基因特性不同的乙型流感病毒。

Aetiologic study on the outbreaks of influenza-like disease in Shenzhen

During March to May in 1994, the outbreaks of influenza like disease occurred in Shenzhen city. The outbreaks were caused by influenza B virus demonstrated by aetiologic and serological studies. The antigenic analysis indicated that the isolates were antigenically similar to B/Shanghai/1/93 and B/Guangdong/8/93 strains (both are B/Victoria/2/87. like virus). The genetic analysis showed that the HA1 genes of the isolates were 1038 nucleotides in length coding for HA1 protein of 346 amino acids which were same as those of B/Shanghai/1/93 virus and that the homogeneity of amino acid sequence on HA1 protein between isolates and B/Shanghai/1/93 virus was as high as 95%. These results further demontrated that the isolates were B/Victoria/2/87 like strains. Meanwhile, this paper also revealed that the two antigenically distinct genetic lineages of influenza B virus were cocirculating in human population.