秦皇岛市各型肝炎病毒感染的血清流行病学研究

对１９９２年至１９９５年在秦皇岛市各医院住院的３２６例肝病患者进行各型肝炎病毒感染的血流流行病学分析，表明在慢性肝炎、肝硬化和原当性肝细胞肝癌中未检出甲型肝炎病毒抗体、乙型肝炎病毒在ＣＨ、ＬＣ和ＨＣＣ的感染率分别为７７．７８％，８４．２１％和９４．２９％，而在急性肝炎中的感染率为２１．５９％。

A seroepidemiological study of hepatitis viruses among the patients with different types of liver disease in Qinhuangdao

This article described a seroepidemiological surveillance in 326 patients with different clinical types of liver disease (acute hepatitis, AH; chronic hepatitis, CH; liver cirrhosis, LC; hepatocellular carcinoma, HCC) from hospitals in Qinhuangdao city during 1992-1995. The results showed that HAV infection could not develop chronic hepatitis. Among 238 patients of CH, LC, and HCC, anti-HAV IgM was not detected. HBV infection was the main pathogenic factor of CH, LC, and HCC with an infection rates of 77.78%, 84.21%, and 94.29%, respectively, the average rate of infection was 3.8 times higher than that in AH. HCV infection rate was increased gradually with development of chronic liver syndrome. Anti-HCV positive rate was 5.56% in CH, but 14.74% and 20.00% in LC and HCC respectively. HEV infection was found in patients with all types of liver disease with an average positive rate of 13.19%. It was not found that single HEV infection developed in CH, LC, and HCC. The average rate of super infection was 17.18% among all the patients, but the super infection rate in LC and HCC was 1.93 times higher than that in AH and CH. It seems that the super infection of HBV and HCV was the main factor for worsened liver symptoms and for developing LC and HCC.