| RNAi 在大肠癌基因治疗中的应用策略和展望 |
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| 引用本文： | 吕伟,张超.RNAi 在大肠癌基因治疗中的应用策略和展望[J].中国普外基础与临床杂志,2005,12(6):637-640. |
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| 作者姓名： | 吕伟 张超 |
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| 作者单位： | 第三军医大学西南医院普通外科,重庆,400038 |
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| 摘 要： | 目的 探讨RNA干扰（RNA interference，RNAi）技术在大肠癌基因治疗研究中的应用。方法复习近几年的相关文献并进行综述。结果RNAi能够高效特异地沉默同源基因表达，可在大肠癌发生、发展多个环节发挥重要作用。结论RNAi技术为大肠癌基因治疗研究开辟了新的途径。
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| 关 键 词： | RNA干扰 大肠癌 基因治疗 |
| 文章编号： | 1007-9424（2005）06-0637-04 |
| 收稿时间： | 2004-10-25 |
| 修稿时间： | 2005-04-11 |
Application and Prospection of RNAi in Colorectal Cancer Gene Therapy |
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| L Wei,ZHANG Chao.Application and Prospection of RNAi in Colorectal Cancer Gene Therapy[J].Chinese Journal of Bases and Clinics In General Surgery,2005,12(6):637-640. |
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| Authors: | L Wei ZHANG Chao |
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| Institution: | L(U) Wei,ZHANG Chao |
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| Abstract: | Objective To explore the application of RNA interference(RNAi) in colorectal cancer gene therapy.Methods The related literatures in recent years were reviewed.Results RNAi causes a high effective and distinctive degradation of mRNA homologous in sequence to the dsRNA.This new technology has been successfully applied to research the genesis and the growth of colorectal cancer.Conclusion RNAi has been a new focus in gene therapy for colorectal cancer. |
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| Keywords: | RNA interference Colorectal cancer Gene therapy |
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