Acute and chronic effects of xanthine oxidase on lung thorax-compliance in guinea pigs |
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| Authors: | O. D. Saugstad G. Becher M. Grossmann G. Merker A. Oddoy B. Lachmann |
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| Affiliation: | (1) Research Institute for Lung Diseases, Berlin, GDR;(2) Department of Pediatrics, The National Hospital, Oslo, Norway;(3) Department of Anesthesiology, Erasmus University, Rotterdam, The Netherlands |
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| Abstract: | Xanthine oxidase was given intratracheally in a single dose to guinea pigs. Lung compliance was measured after 4 h and 14 days respectively. Lung-thorax compliance was significantly lower compared with saline-treated controls both 4 h and 14 days after application of fluid. At 14 days there was a dose-related response between lung-thorax compliance and xanthine oxidase administered in the range 0–1.0 U. Superoxide dismutase (SOD) had a protective effect on xanthine oxidase action at 4 h, but not after 14 days. We suggest that the decreased lung-thorax compliance was caused by superoxide radicals, produced by the hypoxanthine-xanthine oxidase system, damaging lung tissue. We speculate that free oxygen radicals produced by the hypoxanthine-xanthine oxidase system could be an important contributory pathogenetic factor in producing both acute and chronic lung damage in, for instance, premature babies or adults, with respiratory distress syndrome. |
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| Keywords: | Lung-thorax compliance Superoxide radical Superoxide dismutase Xanthine oxidase |
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