自体骨髓干细胞动员移植联合神经营养因子和综合康复治疗持续植物状态

目的观察自体骨髓干细胞（bone marrow stem cells,BMSCs）动员联合神经营养因子及综合康复治疗持续植物状态（persistent vegetative state,PVS）患者的疗效及安全性。方法 60例PVS患者根据治疗方案分为对照组与观察组各30例,对照组给予神经营养因子及综合康复治疗,观察组在对照组治疗基础上行BMSCs动员治疗,比较2组治疗前、后PVS评分。结果治疗前观察组与对照组PVS评分分别为（0.92±0.67）和（0.91±0.75）分,差异无统计学意义（P〈0.05）;治疗后3,6个月、1a观察组PVS评分分别为（12.92±3.55）,（13.58±3.53）,（14.42±3.68）分,对照组分别为（10.45±4.58）,（11.82±5.06）,（12.27±5.06）分,2组比较差异均有统计学意义（P均〈0.05）;治疗后1a,观察组与对照组治愈率分别为80.0%,56.7%,差异有统计学意义（P〈0.05）;治疗过程中2组均未出现明显不良反应。结论 BMSCs动员联合神经营养因子及综合康复治疗PVS安全、疗效满意。

Autologous bone marrow stem cells mobilization combined with neurotrophic factors and comprehensive rehabilitation for patients with persistent vegetative state

Objective To observe the therapeutic effect and safety of autologous bone marrow stem cells（BMSCs） mobilization combined with neurotrophic factors and comprehensive rehabilitation on persistent vegetative state.Methods Sixty cases of persistent vegetative state were divided into the observation group and control group,with 30 cases in each group.Control group received neurotrophic factors and comprehensive rehabilitation,and the observation group received autologous BMSCs mobilization in addition to the therapy in control group.The persistent vegetative state scores were evaluated before and after treatment in two groups.Results There was no significant difference in persistent vegetative state scores between the observation group（0.92±0.67） and control group（0.91±0.75） before treatment（P0.05）.The persistent vegetative state scores were（12.92±3.55）,（13.58±3.53）,and（14.42±3.68） in the observation group,and were（10.45±4.58）,（11.82±5.06）,and（12.27±5.06） in control group in 3 months,6 months and 1 year after treatment,which showed significant differences between these two groups（P0.05）.After 1 year of treatment,the cure rate of the observation group（80.0%） was much higher than that of control group（56.7%）,which showed a significant difference between two groups（P0.05）.No patients experienced seriously adverse reaction during the treatment.Conclusion Autologous BMSCs mobilization combined with neurotrophic factors and comprehensive rehabilitation is effective and safe for persistent vegetative state.