| 非小细胞肺癌中p16/MTS1基因失活及其意义 |
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| 引用本文： | 石永玉,孟红,魏海明,李焱,秦立增,孙广莲,吴惠联,郭进林.非小细胞肺癌中p16/MTS1基因失活及其意义[J].中国癌症杂志,2000,10(1):49-50,58,I002. |
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| 作者姓名： | 石永玉 孟红 魏海明 李焱 秦立增 孙广莲 吴惠联 郭进林 |
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| 作者单位： | 1. 山东医科大学基础医学院微生物学教研室,山东,济南 250012
2. 山东省医学科学院基础医学研究所,山东,济南,250062 |
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| 摘 要： | 目的：研究抑癌基因ｐ１６ＭＴＳ１基因失活与肺癌发生发展的关系。方法：采用双重ＰＣＲ和免疫组化技术分析４８例原发性非小细胞肺癌中ｐ１６基因存在状态。结果：２５例ｐ１６蛋白表达阳性（５２．１％），其中１４例ｐ１６基因第二外显子缺失。有淋巴结转移者和无淋巴结转移者的Ｐ１６蛋白表达阴性率有显著性差异。ｐ１６基因缺失率亦如此。肺鳞癌中ｐ１６蛋白表达阴性率显著高于腺癌。结论：ｐ１６基因存在状态与非小细胞肺癌的
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| 关 键 词： | 非小细胞肺癌 p16基因 基因缺失 MTS1基因 |
| 文章编号： | 1007-3639(2000)01-0049-02 |
Inactivation of p16/MTS1 gene in non-small-cell cancers and its significance |
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| SHI Yong yu,MENG Hong,WEI Hai ming,et al..Inactivation of p16/MTS1 gene in non-small-cell cancers and its significance[J].China Oncology,2000,10(1):49-50,58,I002. |
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| Authors: | SHI Yong yu MENG Hong WEI Hai ming |
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| Abstract: | Purpose:To investigate the genomic status of tumor suppressor gene p16 in primary non small cell lung cancers (NSCLC).Methods:p16 gene was analysed by duplex PCR and immunohistochemistry in 48 primary NSCLC tissues. Results:The negative p16 expression was found in 25 samples (25/48).Twelve cases had deletion in the Exon 2 of p16 gene. There was a statistically significant difference between the NSCLC with lymphnode metastasis and that without lymphnode metastasis.The frequency of negative p16 expression was significantly higher in squamouse cell carcinoma(64.3%) than that in adenocarcinoma(31.3%).Conclusions:Inactivation of p16 gene is related to the histologic types and lymphnode metastasis of NSCLC. |
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| Keywords: | non small cell lung cancer p16 gene gene deletion |
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