| 紫外分光光度法测定盐酸法倔唑片的溶出度 |
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| 引用本文： | 薛梅,扶玲,李楚云,郭林.紫外分光光度法测定盐酸法倔唑片的溶出度[J].中国药房,2007,18(10):771-772. |
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| 作者姓名： | 薛梅 扶玲 李楚云 郭林 |
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| 作者单位： | 广东惠州市中心人民医院药剂科,惠州市,516001 |
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| 摘 要： | 目的:建立测定盐酸法倔唑片溶出度的方法。方法:采用紫外分光光度法,以水为溶媒,在280nm波长处测定其吸收度,并计算溶出度。结果:盐酸法倔唑的线性范围为1～10μg.mL-1(r=0.9999),平均回收率为99.38%(RSD=0.33%);3批样品的30min溶出度均在90%以上。结论:本方法简便、准确,结果可靠,可用于该制剂的溶出度测定。
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| 关 键 词： | 紫外分光光度法 盐酸法倔唑片 溶出度 |
| 文章编号： | 1001-0408(2007)10-0771-02 |
| 收稿时间： | 11 27 2006 12:00AM |
| 修稿时间： | 12 24 2006 12:00AM |
Determination of the Dissolution of Fadrozole Monohydrochloride Tablets by UV |
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| XUE Mei,FU Ling,LI Chuyun,GUO Lin.Determination of the Dissolution of Fadrozole Monohydrochloride Tablets by UV[J].China Pharmacy,2007,18(10):771-772. |
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| Authors: | XUE Mei FU Ling LI Chuyun GUO Lin |
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| Abstract: | OBJECTIVE:To establish a UV method for the determination of the dissolution of fadrozole monohydrochloride tablets.METHODS:The dissolution was measured according to Chinese Pharmacopeia(2005 Edition)with H20 as the solvent.UV spectrophotometry was used,with the detection wavelength at 281nm.RESULTS:Fadrozole monohydrochloride showed a good linear relationship in the range of 1～10μg·mL-1(r=0.999 9).The average recovery was 99.38%,and RSD was 0.33%.The dissolution of 3 batches of samples was all above 90% at 30min.CONCLUSIONS:The method is simple and accurate with reliable results,and can be used for the quality control of Fadrozole monohydrochloride tablets. |
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| Keywords: | UV spectrophotometry Fadrozole monohydrochloride tablets Dissolution |
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