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| 口服复方避孕药对青春期女性骨密度的影响 | |
| 引用本文： | 盖凌,李娟,牟东彦,姜慧,李丽,王晓青,任正达,于小洁.口服复方避孕药对青春期女性骨密度的影响[J].中国计划生育学杂志,2012,20(4):247-249. |
| 作者姓名： | 盖凌 李娟 牟东彦 姜慧 李丽 王晓青 任正达 于小洁 |
| 作者单位： | 1. 山东省计划生育科学技术研究所,济南,250002 2. 山东省高密市计划生育服务站 3. 山东省日照市国际海洋城涛雒计划生育委员会 4. 山东省德州市计划生育指导中心 5. 山东省膝州市计划生育服务站 6. 山东省冠县计划生育服务站 |
| 摘 要： | 目的:观察复方口服避孕药(COCs)妈富隆(去氧孕烯/炔雌醇)对青春期女性骨矿物质密度(BMD)的影响。方法:接纳150例年龄16～18岁女性应用COCs避孕为观察组,用药24个月;接纳150例年龄16～18岁从未应用激素避孕药女性做对照组;应用双能X-线吸收法测量腰椎和股骨颈BMD。结果:观察组用药2年后腰椎和股骨颈BMD从基础值1.010±0.107g/cm3和0.818±0.089g/cm3降低到1.007±0.108g/cm3和0.813±0.090g/cm3,分别降低了0.29%和0.61%;而对照组则从基础值1.008±0.109g/cm3和0.816±0.087g/cm3增高至1.027±0.106g/cm3和0.824±0.089g/cm3,分别增高了1.88%和0.98%;用药2年后,观察组与对照组相比BMD无明显差异(P>0.05)。结论:青春期女性应用COCs避孕2年对BMD无明显影响。 |
| 关 键 词： | 复方口服避孕药 妈富隆 骨矿物质密度 避孕 |
The effect of combined oral contraceptive on bone mineral density in adolescent females |
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| Gai Ling , Li Juan , Mu Dongyan , Jiang Hui , Li Li , Wang Xiaoqing , Ren Zhengda , Yu Xiaojie.The effect of combined oral contraceptive on bone mineral density in adolescent females[J].Chinese Journal of Family Planning,2012,20(4):247-249. | |
| Authors: | Gai Ling Li Juan Mu Dongyan Jiang Hui Li Li Wang Xiaoqing Ren Zhengda Yu Xiaojie |
| Institution: | 1.Shandong Provincial Institute of Science and Technology for Family Planning,Jinan 250002;2.Family Planning Service Station of Gaomi City;3.Family Planning Committee of Taoluo Town in International Ocean City of Rizhao;4.Family Planning Instruction Center of Dezhou City;5.Family Planning Service Station of Tengzhou City;6.Family Planning Service Station of Guan County |
| Abstract: | Objective：To compare adolescents＇ bone mineral density （BMD） between users of Marvelon （desogestrel/ethinylestradiol） and control women.Methods：A total of 150 women aged between 16 and 18 years usd Marvelon for 24 months （the study group） and 150 women aged between 16 and 18 years using nonhormonal contraception were as the control.BMD at both lumbar spine and femoral neck sites were evaluated by dual-energy X-ray absorptiometry.Results：After 24 months of Marvelon oral administration,as compared to baseline,the mean BMD in lumbar spine and femoral neck were decreased by 0.29% and 0.61%,respectively.While in the control group,the mean BMD at both sites were increased by 1.88% and 0.98%,respectively.There were no significant differences in BMD at both lumbar spine and femoral neck sites between the two groups （P0.05）.Conclusion：Two years of Marvelon use had no significant effect on bone density in adolescents. |
| Keywords: | Combined oral contraceptive Marvelon Bone mineral density Contraception |
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