慢性病毒性乙型肝炎患者血清肝纤维化指标检测的临床意义

目的 探讨慢性病毒性乙型肝炎(乙肝)患者血清肝纤维化指标水平与临床的关系.方法 应用放射免疫法及化学发光法检测146例慢性病毒性乙型肝炎患者及40例健康人(对照组)血清肝纤维化指标血清透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、层粘连蛋白(LN)及Ⅲ型前胶原(PCⅢ)水平,并就上述指标与临床肝功能指标关系进行分析.结果 慢性乙肝患者血清HA、Ⅳ-C、LN、PCⅢ水平均不同程度高于对照组(P＜0.05或P＜0.01),在不同病程之间差异有统计学意义(P＜0.05或P＜0.01)；慢性乙肝患者血清Ⅳ-C、PCⅢ水平与血浆PT呈正相关,HA、Ⅳ-C、LN水平与Alb呈负相关,HA水平与TBil呈正相关,PCⅢ水平与ALT呈正相关,LN水平与CHE呈负相关.结论 检测慢性病毒性乙型肝炎患者血清HA、Ⅳ-C、LN、PCⅢ水平,可反映肝纤维化进展情况和肝功能损害程度.

Clinical significance of the serum fibrosis parameters in Chronic hepatitis B patients

Objective To study the relationship between serum fibrosis parameters levels and chronic viral hepatitis B patients.Methods Radioimmunoassay and chemiluminescence were used to test the levels of hyaluronic acid（HA）,collagen type IV（IV-C）,laminin（LN） and procollagen type III（PC III） in 146 cases of chronic hepatitis B and 40 of normal controls,and the relationship with clinical parameters of liver function were analyzed.Results The levels of HA,IV-C,LN,PC Ⅲ in chronic hepatitis B patients were higher than those of normal control group（P〈0.05 or P〈0.01）,there were statistical differen in different course of disease（P〈0.05 or P〈0.01）;The levels of serum IV-C and PCⅢ had positive correlation with plasma PT,the same to HA with TBil and PCⅢ with ALT;The levels of HA,IV-C and LN had negative correlation with Alb,the same to LN with CHE.Conclusion The levels of HA,IV-C,LN and PCⅢ in chronic hepatitis B patients may reflect the situations of hepatic fibrosis and the degrees of liver function damage.