| 人体血清过氧化脂质、抗氧化酶、铜、锌及硒与增龄的关系 |
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| 引用本文： | 张文敏,岳玉平.人体血清过氧化脂质、抗氧化酶、铜、锌及硒与增龄的关系[J].营养学报,1990,12(4):362-366. |
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| 作者姓名： | 张文敏 岳玉平 |
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| 作者单位： | 湖南医科大学营养与食品卫生教研室，湖南娄底地区卫生局，湖南医科大学营养与食品卫生教研室，湖南娄底地区卫生局，湖南医科大学营养与食品卫生教研室，湖南医科大学营养与食品卫生教研室 长沙 410078，长沙 410078，长沙 410078，长沙 410078 |
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| 摘 要： | 观察6～82岁健康男性217人的血清过氧化脂质(LPO)及血抗氧化酶、Cu、Zn、Se与增龄的关系发现,由儿童期进入少年期,LPO即开始增加,老年前期,LPO又增,60岁以上增至最高。儿童期至老年前期,红细胞超氧化物歧化酶(SOD)及血谷胱甘肽过氧化物酶(GSH-Px)一直较稳定。老年期明显下降。Zn、Cu及Zn/Cu水平儿童期最高,青、中年及老年前期波动不大,老年期最低。未观察到各年龄组的血硒含量有显著差异。单相关分析:年龄与LPO呈正相关,与GSH-Px呈负相关,与血Zn/Cu呈负相关。逐步回归分析发现,与年龄关系最密切的是LPO及GSH-Px。提示,LPD似可作为老化的一种指标。如能注意营养,调节体内Cu、Zn水平,增强抗氧化酶活力,可能有助于抑制自由基反应,延缓衰老。
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| 关 键 词： | 衰老 脂质过氧化 超氧化物歧化酶 谷胱甘肽过氧化物酶 铜 锌 硒 |
AGE-RELATED CHANGES OF SERUM LIPID PEROXIDE, ANTIOXIDASE, COPPER, ZINC AND SELENIUM |
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| Zhang Wenmin,Yue Yuping,Hu Manling Zhou Yuliang,Zhou Guangyu,Li Tingyin.AGE-RELATED CHANGES OF SERUM LIPID PEROXIDE, ANTIOXIDASE, COPPER, ZINC AND SELENIUM[J].Acta Nutrimenta Sinica,1990,12(4):362-366. |
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| Authors: | Zhang Wenmin Yue Yuping Hu Manling Zhou Yuliang Zhou Guangyu Li Tingyin |
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| Abstract: | The age-related changes of serum lipid peroxide (LPO), RBC supero-xide dismutase activity (SOD) and glutathione peroxidase activity (GSH-Px), Cu, Zn and Se of blood were observed in 217 normal male persons aged 6~82. It was found that LPO increased significantly with age and SOD, GSH-Px decreased significantly in the elderly (60-70yrs). Blood Zn, Cu and Zn/Cu were highest in the childhood and lowest in the elderly. No significant change of Se with age was observed.The stepwise regression analysis showed that the factors influencing aging mainly were LPO and GSH-Px. It seems that LPO can be used as an indicator of aging.LPO was positively but GSH-Px, SOD, Zn and Cu negatively correlated with aging. |
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| Keywords: | aging LPO SOD GSH-Px Cu Zn Se |
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