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Effects of L-DOPA and L-5-HTP on the visual evoked response
Authors:Iwao Kadobayashi  Masahiko Mori  Kunio Tanaka  Akiteru Toyoshima  Nobukatsu Kato
Affiliation:Department of Psychiatry, Kyoto Prefrectural University of Medicine Kawaramachi-hirokoji, Kamigyo-ku, Kyoto, Japan
Abstract:Small doses (10 and 20 mg/kg) of L-DOPA inhibited the amplitude of the visual evoked response (VER), while large doses (40 and 80 mg/kg) enhanced it. Though low doses (12.5 and 25 mg/kg) of L-5-HTP caused a slight increase in amplitude of the VER, the simultaneous administration of 12.5 mg/kg of L-5-HTP and 10 mg/kg of L-DOPA produced a marked enhancement. The peak latency was prolonged after the injection of any doses of L-DOPA, L-5-HTP, or both.
Keywords:L-DOPA  L-5-HTP  Amplitude  Inhibition  Enhancement  Latnecy  Prolongation
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