红霉素与多潘立酮治疗重症患者急性胃肠损伤的疗效对比

目的比较红霉素与多潘立酮治疗重症患者急性胃肠损伤的临床疗效。方法将符合纳入标准的36例重症患者随机分为2组,各18例。分别应用红霉素和多潘立酮治疗急性胃肠损伤,治疗周期为1周。结果比较2组患者胃液潴留量及急性胃肠损伤分级改善,差异均有统计学意义（P〈0.05）;2组患者治疗后首次排便时间、肠鸣音次数、腹围、腹内压和7d存活率差异无统计学意义。结论红霉素较多潘立酮可显著改善急性胃肠损伤重症患者的胃肠功能。为重症患者急性胃肠损伤的临床治疗提供了新的依据。

Comparison of Curative Effect of Erythromycin and Domperidone in Treatment of Patients With Severe Acute Gastrointestinal Injury

Objective To compare the clinical effects of erythromycin and domperidone on critical patients with gastrointestinal dysfunction. Methods 36 critical patients were included in the study. The patients were divided into two groups randomly. Erythromycin and domperidone were used to treat the acute gastrointestinal injury for 1 week respectively. Results Gastric retention amount in the erythromycin group was remarkable less than domperidone group. The improvement of acute gastrointestinal injury classification in the erythromycin group was also notable less than domperidone group. While there was no significant difference in the first time defecation time, abdominal girth and 7 days survival rate between two groups. Conclusion Erythromycin could significantly improve the gastrointestinal function compared with domperidone in critical patients with acute gastrointestinal injury. Our study provides the new basis on the treatment of critical patients with acute gastrointestinal injury.