| 梅岭霉素发酵过程参数相关分析和优化 |
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| 引用本文： | 庄英萍,陈斌,晏秋鸿,储炬,郭美锦,张嗣良.梅岭霉素发酵过程参数相关分析和优化[J].中国抗生素杂志,2004,29(1):1-3,43. |
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| 作者姓名： | 庄英萍 陈斌 晏秋鸿 储炬 郭美锦 张嗣良 |
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| 作者单位： | 华东理工大学,生物反应器工程国家重点实验室,国家生化工程技术研究中心(上海),上海,200237 |
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| 基金项目： | 国家“九五”攻关项目,项目编号为:2001BA708C07-05 |
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| 摘 要： | 对新型微生物农药梅岭霉素的发酵过程进行研究。通过对发酵过程表征细胞代谢和工程特性的特征参数：氧消耗速率、二氧化碳生成速率、呼吸商、氧传递系数等进行实时在线检测，并利用参数相关分析的方法。对原有工艺不断调整，实现了梅岭霉素发酵过程的初步优化，使发酵效价从原来的150u／ml提高到520u／ml。
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| 关 键 词： | 梅岭霉素 参数检测 相关分析 发酵优化 |
| 文章编号： | 1001-8689(2004)01-0001-03 |
Optimization of meilinmycin fermentation process by parameter correlation analysis |
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| Zhuang Ying-ping,Chen Bin,Yan Qiu-hong,Chu Ju,Guo Mei-jin and Zhang Si-liang.Optimization of meilinmycin fermentation process by parameter correlation analysis[J].Chinese Journal of Antibiotics,2004,29(1):1-3,43. |
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| Authors: | Zhuang Ying-ping Chen Bin Yan Qiu-hong Chu Ju Guo Mei-jin and Zhang Si-liang |
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| Abstract: | The optimization of the fermentation process of melingmycin, which is a new macrolide antibiotic,are presented in this article.On-line monitoring of the parameters,which are characteristics of metabolic flux and engineering aspect,such as OUR,CER,RQ,KLa,are applied to the optimization of the processes. The optimization technology at multi-levels based on parameter correlation technology was proposed,The productivity of melingmycin was thus raised to 520 u/ml from 150 u/ml. |
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| Keywords: | Meilinmycin Parameter monitoring Correlation analysis Fermentation optimization |
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