缺血性卒中患者血浆纤维蛋白原和颈动脉斑块关系的研究

目的 探讨血浆纤维蛋白原水平和颈动脉粥样硬化斑块的关系。方法 通过颈动脉超声检查，将81例缺血性卒中患者分成颈动脉有斑块组和无斑块组，检查两组患者的血浆纤维蛋白原水平和血清总胆固醇，低密度脂蛋白及其他动脉粥样硬化的危险因素。结果 颈动脉有斑块组纤维蛋白原、总胆固醇、低密度脂蛋白水平明显升高，颈动脉硬化的多因素分析表明，纤维蛋白原水平增高是颈动脉粥样斑块形成的危险因之一。结论 纤维蛋白原可能在动脉粥样斑块发生发展过程中起重要作用。

The association between fibrinogen and carotid atherosclerotic plaque in ischemic stroke patients

Objective To assess the relationship between fibrinogen levels and carotid atheromatous plaque.Methods We included 81 patients with ischemic stroke.Carotid artery was assessed by using ultrasonographic methods for the presence of plaque,and subjects were categorized according to the presence(or absence)of plaque.Plasmas fibrinogen,total cholesterol,low density lipoprotein and other risk factors of atherosclerosis were test,either.Rosults The level of fibrinogen,total cholesterol and low density lipoprotein were higher in subjects with carotid atheromatous plaque.The multivariable analysis showed that high plasma fibrinogen levels were one of the main risk factors of carotid atherosclerosis.Conclusion Fibrinogen may play a active role in development and progression of atherosclerotic plaque.