月见草油脂肪酸钠盐影响家兔实验性动脉粥样硬化的病理形态学观察

为进一步探讨月见草油脂肪酸钠盐对家兔实验性动脉粥样硬化的影响，我们将１６只家兔分３组；实验对照组、预防服药组和空白对照组。前二组动物均饲胆固醇，预防服药组同时加饲月见草油脂肪酸钠盐，所有动物均饲等量基本饲料。１５０天后处死动物，在光学显微镜和电子显微镜下观察主动脉壁形态，并测算内膜动脉粥样硬化斑块面积等。结果发现，预防服药组动物主动粥样硬化斑块面积等。结果发现，预防服药组动物主动脉粥样硬化病变程度

Pathomorphological Observation of Erfects of Fatty Acid Sodium or Evening Primrose Oil on Experimental Atherosclerosis in Rabbits

To look for the effective method of prevention and treatment for the atherosclerosis (As), we made this experiment with fatty acid sodium of evening primrose oil for observing the effect of the drug to As in morphology.Methods Sixteen rabbits were divided into one experimental and two control group. In the experimental group, 4. 1 g/kg fatty acid sodium of evening primrose oil was given to each rabbit daily for 150 days. Each rabbit of the experimental and the first control group was fed with 0. 5 g cholesterol per day. After 150 days of feeding, all the rabbits were killed by air embolism. Aorta was investigated by optics and electron microscopy.Results The result indicates that As lesions were significantly improved in experimental group than in control one.Conclusion Our study indicats that fatty acid sodium of evening primrose oil shows remarkable preventive effects on experimental As in rabbits.