5-hydroxytryptamine in platelets of torsion dystonia patients |
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| Authors: | Amos D. Korczyn Jeanette Lazarovits Alexander Dvilanski Yechiel Eshel Ilana Nathan |
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| Affiliation: | Department of Neurology, Tel Aviv Medical Center, Dept. of Physiology and Pharmacology, Tel Aviv University Medical School, and the Hematology Unit, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University, Beer Sheba, Israel |
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| Abstract: | In an effort to explore possible changes in 5-hydroxytryptamine (5-HT) metabolism in idiopathic torsion dystonia (ITD), platelets from patients were studied. Platelet 5-HT concentrations did not differ from those in matched controls. 5-HT uptake by the platelets was also studied, and the results demonstrated significantly higher Km values, but Vmax values were normal among patients. Inhibition by imipramine of 5-HT uptake by platelets taken from ITD patients was also normal. The therapeutic implications of the low affinity of 5-HT to its platelet receptors are discussed. |
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| Keywords: | 5-HT torsion dystonia platelets |
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