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| 小鼠胎盘源干细胞移植对臭氧致衰老模型的影响 | |
| 引用本文： | 李军,张洹,王彦平,颜亮,徐浩,弓健,刘革修.小鼠胎盘源干细胞移植对臭氧致衰老模型的影响[J].广东医学,2010,31(4). |
| 作者姓名： | 李军 张洹 王彦平 颜亮 徐浩 弓健 刘革修 |
| 作者单位： | 1. 暨南大学医学院,血液病研究所,广州,510632 2. 暨南大学医学院,病理生理教研室,广州,510632 3. 暨南大学附属第一医院核医学科,广州,510630 |
| 基金项目： | 国家自然科学基金资助项目(编号:30670902);;广东省自然科学基金资助项目(编号:06300546);;国务院侨办重点学科建设基金项目(编号:200510) |
| 摘 要： | 目的 研究小鼠胎盘源干细胞抗臭氧致衰老的功效。方法 吸入臭氧法制造小鼠衰老模型；剖宫产取小鼠胎盘，密度梯度离心法分离、腹腔注射法移植小鼠胎盘源干细胞；Y染色体原位杂交法检测细胞植入情况；超声检查小鼠心脏；各器官做组织学衰老程度比较、评分。结果 移植30天后治疗组小鼠心脏、肾脏、肺脏、皮肤等器官各衰老指标与模型组之间无统计学差异。结论 单纯移植小鼠胎盘源干细胞不能有效地抗臭氧致衰老。 |
| 关 键 词： | 衰老 臭氧 干细胞 |
The effect of mice placenta stem cell transplantation on mice ozone-induced aging model |
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| LI Jun,ZHANG Huan,WANG Yan-ping,YAN Liang,XU Hao,GONG Jian,LIU Ge-xiu.The effect of mice placenta stem cell transplantation on mice ozone-induced aging model[J].Guangdong Medical Journal,2010,31(4). | |
| Authors: | LI Jun ZHANG Huan WANG Yan-ping YAN Liang XU Hao GONG Jian LIU Ge-xiu |
| Institution: | LI Jun,ZHANG Huan,WANG Yan-ping,YAN Liang,XU Hao,GONG Jian,LIU Ge-xiu.Hematonosis institute of Medical School,Jinan University,Guangzhou 510632,ChinaCorresponding author:LIU Ge-xiu |
| Abstract: | Objective To evaluate the effect of mice placenta stem cell transplantation on mice ozone aging model.Methods A murine oxidative stress model was established via ozone inhalation.Mice placentae were obtained via cesarean section delivery.Placenta stem cells were isolated by gradient centrifugation and transplated into recipients by peritoneal injection.In situ Y chromosomal hybridization was constructed for detection of the transplanted cells.Histological scoring and senility degree of organs were assessed ... |
| Keywords: | senility ozone stem cell |
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