光学相干断层成像比较猪冠状动脉西罗莫司洗脱支架与佐他莫司洗脱支架置入后早期新生内膜覆盖情况

目的应用光学相干断层成像(OCT)比较西罗莫司洗脱支架(SES)与佐他莫司洗脱支架(ZES)置入后1月内新生内膜覆盖情况。方法 18只中华小型猪平均分为3组,每只猪分别在前降支和右冠状动脉随机置入SES和ZES支架各一枚,3组实验动物分别在第7天、14天、28天进行OCT检查,测量新生内膜厚度、支架内面积、管腔内面积、新生内膜面积、面积狭窄百分比和新生内膜覆盖率,比较ZES与SES置入后1月内新生内膜覆盖情况。结果 OCT测量结果显示,支架置入7天和14天时,ZES与SES两种支架丝表面新生内膜厚度和新生内膜覆盖率均存在显著统计学差异(P<0.001)。同样支架术后28天时ZES与SES支架丝表面新生内膜厚度存在显著统计学差异(244.3±282.3μmvs136.3±91.1μm,P<0.001),新生内膜覆盖率存在显著差异(94.88%±2.93%vs90.96%±4.35%,P=0.008)。结论在支架置入后1个月内,ZES与SES比较新生内膜增生更显著,支架丝表面新生内膜覆盖率更高。

Optical Coherence Tomographic Comparison of Neointimal Coverage between Sirolimus-and Zotarolimus-eluting Stents in the early stage of Implantation

Objective Comparison of neointimal coverage between sirolimus-eluting stents （SES） and zotarolimus-eluting stents （ZES） using optical coherence tomography（OCT） in the first month after implantation in porcine coronary artery. Methods Eighteen minipigs were divided into three groups. Each animal was implanted with both SES and ZES in right coronary artery and left anterior descending artery respectively and random- ly. Three groups of porcine were evaluated with OCT at 7,14 and 28 days respectively after implantation. Neointimal hyperplasia （NIH） thickness, in- stent area, luman area, NIH area, NIH coverage rate were evaluated. Results OCT showed that there were significant difference between ZES and SES in NIH thickness and NIH coverage rate both 7 and 14 days after implantation （P 〈 0.001）. There were also significant difference in NIH thickness （244.3 ~ 282.3 ~ m vs 136.3 ~ 91.1 ju m, P 〈 0.001） and NIH coverage rate （94.88% ~ 2.93% vs 90.96% ~ 4.35%, P =0.008） 28 days after implanta- tion. Conclusion In the first month after implantation, neointimal hyperplasia was greater with ZES compare with SES, and the neointimal coverage with ZES was better.