| 长链非编码RNA与心血管发育及疾病的关系 |
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| 引用本文： | 王静,蒋晓燕.长链非编码RNA与心血管发育及疾病的关系[J].中国分子心脏病学杂志,2013,13(2):505-508. |
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| 作者姓名： | 王静 蒋晓燕 |
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| 作者单位： | 200092上海,同济大学医学院 病理与病理生理学系;200092上海,心律失常教育部重点实验室(同济大学) |
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| 基金项目： | 国家973项目，国家基金委重大国际(地区)合作项目，国家自然科学基金面上项目，国家自然科学基金青年基金项目 |
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| 摘 要： | 长链非编码RNA(long non-coding RNA,lncRNA)是一类转录本长度超过200nt功能性RNA分子。研究表明lncRNA参与调控机体的生长发育、细胞凋亡、增殖、分化等,与多种疾病密切相关。目前lncRNA的功能和作用机制尚不清楚,已有一些研究证实lncRNAs是参与心血管疾病发生发展的重要调控分子。现将lncRNA对心脏的发育及与心血管疾病的作用机制研究进展作一综述。
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| 关 键 词： | lncRNA 心脏发育 心脏疾病 |
The Relationship Between Long Non-coding RNA and Cardiovascular Development and diseases |
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| Wang jing,Jiang Xiao-yan,Chen Yi-han.The Relationship Between Long Non-coding RNA and Cardiovascular Development and diseases[J].Molecular Cardiology of China,2013,13(2):505-508. |
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| Authors: | Wang jing Jiang Xiao-yan Chen Yi-han |
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| Institution: | Wang Jing,Jiang Xiao-Yan2,Chen Yi-Han IDepartment of Pathology and Pathophysiology, Tongji University School of Medicine,Key Laborato of Arrhythmias of the Minist of Education, Tongi University, Shanghai 200092,China. |
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| Abstract: | Long non-coding RNA （IncRNA） is a functional RNA molecule longer than 200 nucleotides. They are involved in development, apoptosis, proliferation, and associated with many diseases. Although the functions and mechanism of IncRNA remain unclear, some studies have in- dicated that lncRNAs are key regulatory molecules involved in pathophysiology of cardiovascular development and diseases. In this paper, we review the research progress about lncRNA function and its association with cardiovascular development and diseases. |
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| Keywords: | lncRNA Cardiovascular Development Cardiovascular Diseases |
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