Fine needle aspiration cytology of invasive micropapillary carcinoma of the breast |
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Authors: | Lui Philip C W Lau Patrick P L Tse Gary M K Tan Puay Hoon Lo Regina C L Tang Victor W L Ng Wai Kuen Somali Anjali Mak Kong Ling Thomas Teresa M M Chan Ngot Htai Hiang Tin Tin Chan Norman H L |
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Affiliation: | Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. philiplui@cuhk.edu.hk |
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Abstract: | AIM: To determine the pathognomonic diagnostic cytological features of invasive micropapillary carcinoma of the breast which is a poor prognostic subtype of infiltrating ductal carcinoma. METHODS: A series of 20 histologically proven tumours were reviewed retrospectively to evaluate the various cytological features, including tumour morules, isolated malignant cells, staghorn epithelial structures, mucinous background and apocrine metaplasia. RESULTS: Tumour morules formation and isolated malignant cells were the two most reliable and constant cytological features, being present in 75% (15/20 cases) of cases. Staghorn epithelial structures were present in 35% (7 cases). Mucinous background (2 cases, 10%) and apocrine metaplasia (4 cases, 20%) of the tumour cells were seen in a few cases only and did not appear very helpful. CONCLUSION: Tumour morules formation, isolated malignant cells and staghorn epithelial structures are the most reliable cytological features, and the presence of these should raise suspicion of invasive micropapillary carcinoma. |
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Keywords: | Invasive micropapillary carcinoma, breast fine needle aspiration cytolog |
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