柴芪口服液抗抑郁作用实验研究

摘要目的：实验观察柴芪口服液的抗抑郁作用。方法：将动物随机分为空白对照组、阳性对照（氟西汀）组、柴芪口服液高、中、低剂量组，分别灌胃给予同等容积的相应药物，qd，连续给予14d，末次给药后40min，采用小鼠悬尾实验、强迫游泳实验及开场实验等方法观察柴芪口服液的抗抑郁作用。结果：在小鼠强迫游泳实验和小鼠悬尾实验中，柴芪口服液大剂量（生药6．4g·kg^-1）能明显缩短两种“行为绝望”模型小鼠的不动时间；在小鼠开场实验中，柴芪口服液6．4g·kg^-1使小鼠水平方向活动次数显著提高，与对照组比较有显著性差异（P＜0．05）。结论：柴芪口服液具有抗抑郁作用。

Study on Anti-depression Effects of Chaiqi Oral Liquid in Mice

To investigate the antidepressant action of Chaiqi oral liquid in mice. Method： Mice were randomly divided into control group, fluoxetine group and Chaiqi oral liquid high, middle, low dose groups. Different groups were given corresponding medicine with same volume once per day for 14 days. The tail suspension test （TST）, forced sw, mmmg test（FST）and open nero test were applied to evaluate antidepressant activities. Result： Compared with the control group, the immobility time of TST and FST was shorted and crossing score of mice in open field test was increased significantly in high dose Chaiqi oral liquid （ 6.4g·kg^-1） group. Conclusion： Chaiqi oral liquid has certain antidepressant-like effect.