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| 基因芯片技术检测新疆哈萨克族食管癌HPV感染状况及基因型分析 | |
| 引用本文： | 刘琳,王刚刚,李洪安,胡建明,常彬,赵瑾,徐康宁,李锋.基因芯片技术检测新疆哈萨克族食管癌HPV感染状况及基因型分析[J].农垦医学,2011,33(2):114-117. |
| 作者姓名： | 刘琳 王刚刚 李洪安 胡建明 常彬 赵瑾 徐康宁 李锋 |
| 作者单位： | 1. 石河子大学医学院病理学,新疆石河子,832002 2. 石河子大学医学院病理学教研室/新疆地方与民族高发病教育部重点实验室,新疆石河子,832002 3. 新疆乌鲁木齐友谊医院病理科,乌鲁木齐,830049 |
| 基金项目： | 国际科技合作与交流专项，"十一五"国家科技支撑计划项目 |
| 摘 要： | 目的：探讨人乳头瘤状病毒（Human papillomavirus,HPV）在新疆哈萨克族食管癌中的型别分布情况。方法：采用基因芯片技术对194例哈族食管癌石蜡组织标本进行23种HPV基因型别检测,同时,对检测HPV单一型别阳性样本进行DNA测序验证。结果：共检测出7种HPV型别,HPV总感染率为32.5%（63/194）,其中,高危型HPV16的感染率最高为27.8%（54/194）,检出其他高危型为HPV18、HPV35和HPV52。低危型中HPV6感染率最高为5.2%（10/194）,其他低危型HPV11,HPV43各检出1例。多重感染率为11.1%（7/63）,并全为二重感染。按照食管癌类型、年龄、性别对哈族食管癌中的HPV感染状况进行比较分析,差异均无统计学意义。食管鳞癌中HPV基因型分布也与病理分化程度无关。结论：新疆哈萨克族食管癌存在HPV感染,HPV感染可能与食管癌的发生、发展有一定的相关性,且HPV16是哈族食管癌的主要感染型别。 |
| 关 键 词： | 人乳头状瘤病毒 食管癌 基因分型 哈萨克族 |
Analysis of human papillomavirus infection state and genotypes in Kazakh esophageal carcinomas in Xinjiang by Gene Chip Technology |
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| LIU Lin,WANG Ganggang,LI Hongan,HU Jianming,CHANG Bin,ZHAO Jin,XU Kangning,LI Feng.Analysis of human papillomavirus infection state and genotypes in Kazakh esophageal carcinomas in Xinjiang by Gene Chip Technology[J].Agricultural Reclamation Medicine,2011,33(2):114-117. | |
| Authors: | LIU Lin WANG Ganggang LI Hongan HU Jianming CHANG Bin ZHAO Jin XU Kangning LI Feng |
| Institution: | LIU Lin1,WANG Ganggang,LI Hongan,HU Jianming,CHANG Bin,ZHAO Jin,XU Kangning,LI Feng(1.Class 2008 of Master of pathology,Shihezi Uniuersity school of Medicine,2.Department of Pathology,Shihezi University School of Medicine/Laboratory of Xinjiang Endemic and Ethnic Disease,Xinjiang Shehezi,832002,3.Xinjiang Urumqi Friendship Hospital,Urumqi,830049) |
| Abstract: | Objective:To investigate the distribution of types of human papillomavirus(HPV) in Xinjiang Kazakh esophageal carcinoma. Methods:23 HPV genotypes were detected by gene chip in 194 paraffin-embedded Kazakh esophageal carcinoma tissues,Meanwhile the single subtypes of HPV positive were sequenced. Results:Totally 7 genotypes were detected.The total infection rate of HPV was 32.5%(63/194).The positive rate of HPV16 infection was 27.8%(54/194) among the High-Risk HPV,indicating it was the most common infection.O... |
| Keywords: | human papillomavirus esophageal carcinoma Genotyping Kazakh |
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