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布地奈德联合硫酸沙丁胺醇及氨溴索雾化吸入治疗70岁以上慢性阻塞性肺疾病急性加重期患者的临床观察
引用本文:顾珏,张凌云. 布地奈德联合硫酸沙丁胺醇及氨溴索雾化吸入治疗70岁以上慢性阻塞性肺疾病急性加重期患者的临床观察[J]. 中国综合临床, 2011, 27(8). DOI: 10.3760/cma.j.issn.1008-6315.2011.08.013
作者姓名:顾珏  张凌云
作者单位:解放军海军总医院老年科,北京,100048
摘    要:目的 观察布地奈德混悬液联合硫酸沙丁胺醇溶液及氨溴索注射液雾化吸入治疗70岁以上慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效.方法 58例70岁以上AECOPD患者,在常规治疗的基础上加用布地奈德混悬液联合硫酸沙丁胺醇溶液及氨溴索注射液雾化吸入治疗;对照组56例AECOPD患者,给予常规低流量吸氧、抗感染、平喘化痰、加强营养支持等治疗;比较2组的临床效果.结果 治疗组总有效率为89.66%(52/58),对照组总有效率为76.79%(43/56),2组差异有统计学意义(χ2=6.46,P=0.007).2组患者治疗前后血气分析(pH、PaCO2、PaO2)、肺功能(FEV1/FVC、FEV1占预计值%)均改善,组内比较差异均有统计学意义(P均<0.05),血气分析改善组间比较差异无统计学意义(P均>0.05),肺功能改善组间比较差异有统计学意义(P<0.05).2组患者在治疗过程中均无口咽部念珠菌病发生.结论 70岁以上AECOPD患者在常规治疗的基础上,加用布地奈德混悬液联合硫酸沙丁胺醇溶液及氨溴索注射液雾化吸入,疗效好,不良反应发生率低.
Abstract:
Objective To assess the clinical efficacy of budesonide in combination with salbutamol sulfate and ambroxol through fog inhalation in the treatment of elderly patients older than 70 years with acute exacerbation chronic obstructive pneumonia disease (AECOPD). Methods A total of 58 elderly patients older than 70 years with AECOPD were randomly assigned to receive medication of budesonide in combination with salbutamol sulfate and ambroxol through fog inhalation in addition to conventional therapy ( n = 58 treatment group). In the control group,56 AECOPD patients received conventional therapy (including oxygen uptaking,anti-infection, medication, relieving asthma, eliminating sputum, nutritional support, et al). Results The overall effective rate in the treatment group was 76.79% (43/56) ,which was significantly lower than that in the control group 89. 66% (52/58) ( χ2 = 6. 46, P = 0. 007 ). Blood gas analysis ( pH, PaCO2, PaO2 ) and lung function ( FEV1/FVC, FEV1 occupy prospect% ) outcome were significantly improved after treatment (Ps < 0.05 ). We found no significant difference in the comparison of the blood gas analysis improvement between the treatment and control ( Ps > 0. 05 ), whereas significant difference was observed in the improvement on lung function between the two groups (P < 0. 05 ). Conclusion Combined budesonide with salbutamol sulfate and ambroxol through fog inhalation in addition to conventional therapy has a significant better effect and less side effects on the treatment of AECOPD patients older than 70 years.

关 键 词:慢性阻塞性肺疾病  布地奈德  硫酸沙丁胺醇  氨溴索

Clinical observation on patients older than seventy years with AECOPD treated with budesonide in combination with salbutamol sulfate and ambroxol through fog inhalation
GU Jue,ZHANG Ling-Yun. Clinical observation on patients older than seventy years with AECOPD treated with budesonide in combination with salbutamol sulfate and ambroxol through fog inhalation[J]. Clinical Medicine of China, 2011, 27(8). DOI: 10.3760/cma.j.issn.1008-6315.2011.08.013
Authors:GU Jue  ZHANG Ling-Yun
Abstract:Objective To assess the clinical efficacy of budesonide in combination with salbutamol sulfate and ambroxol through fog inhalation in the treatment of elderly patients older than 70 years with acute exacerbation chronic obstructive pneumonia disease (AECOPD). Methods A total of 58 elderly patients older than 70 years with AECOPD were randomly assigned to receive medication of budesonide in combination with salbutamol sulfate and ambroxol through fog inhalation in addition to conventional therapy ( n = 58 treatment group). In the control group,56 AECOPD patients received conventional therapy (including oxygen uptaking,anti-infection, medication, relieving asthma, eliminating sputum, nutritional support, et al). Results The overall effective rate in the treatment group was 76.79% (43/56) ,which was significantly lower than that in the control group 89. 66% (52/58) ( χ2 = 6. 46, P = 0. 007 ). Blood gas analysis ( pH, PaCO2, PaO2 ) and lung function ( FEV1/FVC, FEV1 occupy prospect% ) outcome were significantly improved after treatment (Ps < 0.05 ). We found no significant difference in the comparison of the blood gas analysis improvement between the treatment and control ( Ps > 0. 05 ), whereas significant difference was observed in the improvement on lung function between the two groups (P < 0. 05 ). Conclusion Combined budesonide with salbutamol sulfate and ambroxol through fog inhalation in addition to conventional therapy has a significant better effect and less side effects on the treatment of AECOPD patients older than 70 years.
Keywords:Acute exacerbation chronic obstructive pneumonia disease  Budesonide  Salbutamol sulfate  Ambroxol
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