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Chemopreventive efficacies of rosiglitazone, fenretinide and their combination against rat mammary carcinogenesis
Authors:Hilal Kocdor  Mehmet Ali Kocdor  Tulay Canda  Duygu Gurel  Ruksan Cehreli  Osman Yilmaz  Mehmet Alakavuklar  Gul Guner
Affiliation:(1) Division of Hematology/Oncology, Department of Internal Medicine, Weill Cornell Medical College, 525 East 68th Street, J-321, New York, NY 10021, USA;(2) Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, C361 Med Inn, P.O. Box 5848, Ann Arbor, MI 48109, USA;(3) Division of Hematology and Oncology, Karmanos Cancer Institute, 4100 John R, Detroit, MI 48201, USA;(4) Cancer Therapy Evaluation Program, National Cancer Institute, Rockville, MD, USA;(5) Biostatistics Core Facility, Department of Urology, University of Michigan Cancer Center, 300 N. Ingalls, 8D15, Ann Arbor, MI 48109-0473, USA;(6) Providence Cancer Institute, 22301 Foster Winter Drive, Southfield, MI 48075, USA;(7) Lab of Human Toxicology Pharmacology, NCI-Frederick, P.O. Box B, Building 431 Room 104, Frederick, MD 21702-1201, USA;(8) National Cancer Institute, 6130 Executive Blvd, Ste 7131, Bethesda, MD 20892-7426, USA;(9) Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Drive, C350 Med Inn, P.O. Box 5848, Ann Arbor, MI 48109-5848, USA
Abstract:

Introduction  

Peroxisome proliferator-activated receptor gamma (PPAR-γ) and retinoic acid receptors (RAR/RXR) belong to the nuclear steroid receptor family. In vitro studies have suggested that PPAR-γ ligands are highly effective in preventing mammary tumours and these effects are enhanced by some retinoids. However, in vivo anti-initiator and anti-promoter efficacies of this combination are not clear.
Keywords:
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