| 金鸡菊提取物对血管环舒张作用的探讨 |
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| 引用本文： | 曹燕,庞市宾,徐磊,哈木拉提,刘晓燕,孙玉华.金鸡菊提取物对血管环舒张作用的探讨[J].农垦医学,2011,33(2):148-152. |
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| 作者姓名： | 曹燕 庞市宾 徐磊 哈木拉提 刘晓燕 孙玉华 |
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| 作者单位： | 1. 石河子大学药学院,新疆石河子,832002
2. 新疆维吾尔自治区药物研究所,乌鲁木齐,830004 |
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| 基金项目： | 新疆维吾尔自治区重点实验室自然基金 |
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| 摘 要： | 目的:观察金鸡菊提取物对大鼠胸主动脉血管环效应并探讨其作用机制.方法:采用大鼠离体胸主动脉环灌流,记录张力变化.结果:金鸡菊提取物剂量依赖性地舒张由苯肾上腺素(PE)或KCl预收缩的大鼠胸主动脉环,其舒张血管作用不依赖内皮;在无钙灌流液中,用KCl(60mmol·L-1)去极化去除内皮的血管环后,逐步加入Ca2+,使血...
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| 关 键 词： | 金鸡菊提取物 胸主动脉 血管舒张 钙通道 |
Relaxant effects of Coreopsis extracts on rat thoracic aortic and underlying mechanisms |
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| CAO Yan,PANG Shi-bin,XU Lei,HA Mu-la-ti,LIU Xiao-yan,SUN Yu-hua.Relaxant effects of Coreopsis extracts on rat thoracic aortic and underlying mechanisms[J].Agricultural Reclamation Medicine,2011,33(2):148-152. |
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| Authors: | CAO Yan PANG Shi-bin XU Lei HA Mu-la-ti LIU Xiao-yan SUN Yu-hua |
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| Institution: | CAO Yan1,PANG Shi-bin2,XU Lei2,HA Mu-la-ti2,LIU Xiao-yan2,SUN Yu-hua2(1.School of Pharmacy,Shihezi University,Xinjiang Shihezi,832002,2.Xinjiang Institute of Materia Medica,Urumqi,830004) |
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| Abstract: | Objective:To investigate the relaxant effects and mechanisms of Coreopsis extracts on isolated thoracic aorta of rat. Methods:Study was performed with the model of isolate rat thoracic aorta rings in organ bath.and the contractile changes were recorded. Results:Coreopsis extracts obviously relaxed rat aortic rings pre-contracted by PE or KCl with endothelium intact or denuded in a dose dependent manner.Cumulative application of Ca2+ induced a concentration-dependent contraction in rat aortic rings without e... |
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| Keywords: | Coreopsis extracts thoracic aorta ring vasorelaxation Ca2 channel |
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