Synthesis and antiaggregant activity of 8-amino-substituted 1-alkyl-3-methyl-7- (thietanyl-3)xanthines |
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| Authors: | Yu. V. Shabalina F. A. Khaliullin A. A. Spasov L. V. Naumenko V. A. Sysoeva |
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| Affiliation: | (1) State Institute of Pharmacology, Tomsk Scientific Center, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia;(2) Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, Syktyvkar, Russia;(3) Siberian State Medical University, Tomsk, Russia; |
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| Abstract: | A series of 8-amino-substituted 1-alkyl-3-methyl-7-(thietanyl-3)xanthines have been synthesized using 1-ethyl-, 1-propyl-, and 1-hexyl-8-bromo-3-methyl-7-(thietanyl-3)xanthines and various reactants including monoethanolamine, tris-amine, and piperazine. The target 8-amino-substituted 1-alkyl-3-methyl-7- (thietanyl-3)xanthines were obtained in 54 – 88% yields. The structures of the synthesized compounds were determined using IR spectroscopy and PMR spectrometry. Most of the synthesized compounds exhibit antiaggregant activity. |
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