生物止血材料医用胶黏合儿童额面部开放性伤口创面的可行性

背景：生物止血材料医用胶在体液、血液作用下的扩散性好，可迅速发生聚合反应，产生较理想的止血、促进愈合等作用。 目的：观察医用胶作为止血材料在儿童额面部开放性伤口创面中的临床应用价值。 方法：选择以生物材料医用胶黏合额面部开放性伤口的1 218例儿童为观察组，以常规丝线缝合额面部开放性伤口的600例儿童为对照组，比较两组伤口愈合时间、术后伤口出血情况、缝线反应、色素沉着情况及瘢痕增生程度。 结果与结论：观察组手术时间、出血量及伤口愈合时间均少于对照组(P < 0.05)，有效止血率高于对照组(P < 0.05)；观察组中1 215例伤口Ⅰ期愈合，对照组中586例伤口Ⅰ期愈合。随访12个月，观察组瘢痕愈合平整，无线结瘢痕及针眼瘢痕，与临近皮肤肤色相近，美容效果良好；对照组瘢痕较明显，可见线结瘢痕及针眼瘢痕，大部分伤口周围出现红斑、硬结及瘢痕增生。使用生物止血材料医用胶黏合儿童额面部开放性伤口具有良好的生物相容性及美容效果，且使用安全、方便。中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 

Feasibility of medical glue for open wound of the frontal plane in children

BACKGROUND:Medical glue as a biological hemostatic material shows a good diffusivity in body fluids and blood, and has a rapid polymerization reaction, which plays an ideal hemostatic effect and promotes wound healing. OBJECTIVE:To investigate the clinical value of medical glue as a hemostatic material in the open wound of the frontal plane in children. METHODS:Totally 1 218 children with open wounds of the frontal plane treated with medical glue were enrolled as observation group, and another 600 children with open wounds of the frontal plane treated with silk sutures as control group. Wound healing time, postoperative wound bleeding, suture reaction, pigmentation and scar hyperplasia were compared between the two groups. RESULTS AND CONCLUSION:Compared with the control group, the operative time, blood loss and wound healing time were all less in the observation group (P < 0.05), and the effective bleeding rate was higher in the observation group (P < 0.05). Stage I wound healing occurred in 1 215 cases of the observation group, and 586 cases of the control group. At the end of 12-month follow-up, healed scar formed with no knot scar and needle scar, the skin color was similar and cosmetic results were good in the observation group; in the control group, there were more obvious scars, visible knot and needle scars, and erythema, induration and hypertrophic scars were found around the most wounds. The medical glue for open wounds of the frontal plane in children has good biocompatibility and cosmetic results, which is safe and convenient in clinical use.