Interleukin-6 Gene Polymorphisms,Dietary Fat Intake,Obesity and Serum Lipid Concentrations in Black and White South African Women |
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Authors: | Yael T Joffe Lize van der Merwe Juliet Evans Malcolm Collins Estelle V Lambert Alison September Julia H Goedecke |
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Institution: | 1.UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town 7505, South Africa; E-Mails: (Y.T.J.); (L.M.); (J.E.); (M.C.); (E.V.L.); (A.S.);2.Department of Statistics, University of Western Cape, Cape Town 7505, South Africa;3.Non-communicable Disease Research Unit (NCDRU), South African Medical Research Council, PO Box 19070, Tygerberg, Cape Town 7505, South Africa |
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Abstract: | This study investigated interactions between dietary fat intake and IL-6 polymorphisms on obesity and serum lipids in black and white South African (SA) women. Normal-weight and obese, black and white women underwent measurements of body composition, serum lipids and dietary fat intake, and were genotyped for the IL-6 −174 G>C, IVS3 +281 G>T and IVS4 +869 A>G polymorphisms. In black women the IVS4 +869 G allele was associated with greater adiposity, and with increasing dietary fat intake adiposity increased in the IVS3 +281 GT+GG and IVS4 +869 AA or AG genotypes. In white women, with increasing omega-3 (n-3) intake and decreasing n-6:n-3 ratio, body mass index (BMI) decreased in those with the −174 C allele, IVS3 +281 T allele and IVS4 +869 AG genotype. In the white women, those with the IVS3 +281 T allele had lower triglycerides. Further, with increasing n-3 polyunsaturated fatty acid (PUFA); triglyceride and total cholesterol:high-density lipoprotein cholesterol (T-C:HDL-C) ratio decreased in those with the −174 C allele. In black women, with increasing total fat intake, triglycerides and T-C:HDL-C ratio increased in those with the IVS4 +869 G allele. This study is the first to show that dietary fat intake modulates the relationship between the IL-6 −174 G>C, IVS3 +281 G>T and IVS4 +869 A>G polymorphisms on obesity and serum lipids in black and white SA women. |
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Keywords: | IL-6 gene dietary fat obesity serum lipids ethnicity |
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