比较5种不同盖髓剂长期护髓的差异

背景：在深龋治疗中，采用盖髓剂间接盖髓，可诱导牙髓牙本质复合体形成牙本质桥，保护牙髓组织免受刺激，保存活髓，彻底避免并发症的出现，临床成功率较高。目的：对比5种不同氢氧化钙制剂间接盖髓的临床效果差异。方法：纳入236例深龋患者，随机分组，分别采用双组分氢氧化钙粉剂(n=46)、单组分注射剂型化学固化氢氧化钙制剂Metapex(n=47)、化学固化型氢氧化钙制剂Dycal(n=45)、单组分光固化氢氧化钙制剂Ionosit-Baseliner(n=49)及单组分光固化氢氧化钙制剂Calcimol LC(n=49)间接盖髓，盖髓后第1，6，12，24个月随访，观察牙髓状况、充填体是否脱落及根尖状况等。结果与结论：随访1，6，12个月，5组间盖髓成功率比较差异无显著性意义(P > 0.05)；随访24个月时，双组分氢氧化钙粉剂组盖髓成功率低于其他4组(P < 0.05)，后4组间盖髓成功率比较差异无显著性意义(P > 0.05)。表明氢氧化钙制剂Metapex、Dycal、Ionosit-Baseliner及Calcimol LC对深龋治疗均具有良好的盖髓效果，可长期护髓。中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程全文链接：

Long-term effects of five kinds of pulp capping agents: a comparative study

BACKGROUND: In the deep caries treatment, the pulp capping agent used in indirect pulp can induce the formation of dentin bridge (the complex of dental pulp and dentin), to protect the pulp tissue from stimulus and save the pulp vitality, completely avoid the occurrence of complications, with a higher clinical success rate. OBJECTIVE: To evaluate the differences in clinical efficacy of five kinds of calcium hydroxide preparations. METHODS: Totally 236 patients with deep caries were selected and randomized to undergo indirect pulp with the double-component calcium hydroxide powder (n=46), Metapex with one-component injection dosage form and the chemical curing calcium hydroxide preparation (n=47), Dycal with the chemical curing calcium hydroxide preparation (n=45), Ionosit-Baseliner (n=49) and Calcimol LC (n=49) with one-component and the light curing calcium hydroxide preparation. The status of the dental pulp, the restoration and the root tip were observed at 1, 6, 12 and 24 months after operation. RESULTS AND CONCLUSION: There was no significant difference between the five groups in the success rate of indirect pulp capping at 1, 6 and 12 months (P > 0.05). At 24 months, the success rate of indirect pulp capping in the double-component calcium hydroxide powder group was lower than that in the other four groups (P < 0.05), but there was no significant difference between the latter four groups (P > 0.05). Metapex, Dycal, Ionosit-Baseliner and Calcimol LC all have a good effect on indirect pulp capping to deep caries, which can be used as agents for long-term pulp protection.