聚乳酸-乙醇酸共聚物/羟基磷灰石复合支架修复喉软骨缺损 |
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作者姓名: | 刘永刚 周香桃 |
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作者单位: | 南阳市中心医院耳鼻喉科一病区,河南省南阳市 473000;河南大学医学院,河南省开封市 475004 |
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摘 要: | 背景:喉软骨缺损传统的修复方法受到供体来源、排斥反应等限制,因而难以推广。
目的:观察聚乳酸-乙醇酸共聚物/羟基磷灰石复合支架修复喉软骨缺损的效果。
方法:将20只Wistar 大鼠随机分为聚乳酸-乙醇酸共聚物/羟基磷灰石复合支架组和聚乳酸-乙醇酸共聚物支架组,建立喉软骨缺损模型后分别采用聚乳酸-乙醇酸共聚物/羟基磷灰石复合支架和聚乳酸-乙醇酸共聚物支架修复。
结果与结论:聚乳酸-乙醇酸共聚物/羟基磷灰石复合支架组大鼠造模后3,5,7 d时喉骨缺损直径显著小于聚乳酸-乙醇酸共聚物支架组;聚乳酸-乙醇酸共聚物/羟基磷灰石复合支架组大鼠喉软骨缺损部位基本修复,表面平整,且与周围其他组织之间没有明显界限;而聚乳酸-乙醇酸共聚物支架组大鼠喉软骨缺损部位存在凹陷,表面粗糙,和周围组织存在明显界限。说明聚乳酸-乙醇酸共聚物/羟基磷灰石复合支架能够促进喉软骨缺损部位修复,修复喉软骨缺损的效果更理想。
中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程
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关 键 词: | 生物材料 软骨生物材料 聚乳酸-乙醇酸共聚物/羟基磷灰石复合支架 pickering乳液法 修复 聚乳酸-乙醇酸共聚物支架 孔隙率 |
Polylactic acid-glycolic acid copolymer/hydroxyapatite composite scaffold repairs laryngeal cartilage defect |
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Authors: | Liu Yong-gang Zhou Xiang-tao |
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Institution: | First Ward, Department of Otolaryngology, Nanyang City Central Hospital, Nanyang 473000, Henan Province, China; Henan University School of Medicine, Kaifeng 475004, Henan Province, China |
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Abstract: | BACKGROUND: The traditional repair methods for laryngeal cartilage defect are restricted by donor source, rejection, which are difficult to be popularized.
OBJECTIVE: To investigate the effect of polylactic acid-glycolic acid copolymer/hydroxyapatite composite scaffold in repair of laryngeal cartilage defect.
METHODS: A total of 20 Wistar rats were randomly divided into polylactic acid-glycolic acid copolymer/hydroxyapatite composite scaffold and polylactic acid-glycolic acid copolymer scaffold groups. Polylactic acid-glycolic acid copolymer/hydroxyapatite composite scaffold and polylactic acid-glycolic acid copolymer scaffold were respectively used for repair after the establishment of laryngeal cartilage defect models.
RESULTS AND CONCLUSION: The laryngeal cartilage defect diameter of rats at 3, 5 and 7 days after modeling in the polylactic acid-glycolic acid copolymer/hydroxyapatite composite scaffold group was significantly smaller than that in the polylactic acid-glycolic acid copolymer scaffold group. The laryngeal cartilage defect of rats in the polylactic acid-glycolic acid copolymer/hydroxyapatite composite scaffold group was basically repaired and presented with a smooth surface, and there were no clear boundaries with surrounding tissues; however, the laryngeal cartilage defect of rats in the polylactic acid-glycolic acid copolymer scaffold group had indentations with a rough surface, and there were obvious boundaries with surrounding tissues. These results demonstrate that polylactic acid-glycolic acid copolymer/hydroxyapatite composite scaffold can promote the repair of laryngeal cartilage defect part, and its repair effect is more ideal.
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