Higher level of heme oxygenase-1 in patients with stroke than TIA |
| |
Authors: | Xin Li Guangfu Song Yuling Jin Hongwei Liu Changqing Li Chengwu Han Shiyan Ren |
| |
Institution: | 1.Department of Neurology, 2.Department of Neurosurgery, 3.Department of Ophthalmology, First Affiliated Hospital of Jiamusi University, Jiamusi 154000, China; 4.Department of Invasive Technology, Ditan Hospital, Capital Medical University, Beijing 100015, China; 5.Clincical Laboratory, 6.Cardiovascular Surgery, China Japan-Friendship Hospital, Beijing 100029, China |
| |
Abstract: | BackgroundThere is a reverse relationship between serum bilirubin level and incidence of stroke, heme oxygenase-1 (HO-1) can catalyze heme into bilirubin, it is unknown the association of HO-1 level with risk of stroke.MethodsSixty patients with stroke and fifty patients with transient ischemic attack (TIA) were recruited. Serum level of HO-1, total and direct bilirubin, alanine transaminase, live function, lipid profile and infection status of patients were measured.ResultsSignificant differences were found between two groups in terms of serum levels of HO-1 (163.6±58.7 vs. 141.2±49.7, P=0.032), total bilirubin (10.1±4.6 vs. 15.8±2.7, P<0.001), direct bilirubin (3.2±2.1 vs. 5.9±1.2, P<0.001), fasting glucose (6.7±3.1 vs. 4.9±1.3, P<0.001), cholesterol (4.4±1.1 vs. 3.9±0.8, P=0.005) and diastolic blood pressure (DBP) (84.9±9.4 vs. 81.3±9.2, P=0.046). In multivariate analysis, serum direct bilirubin (OR, 2.83; P<0.001), total bilirubin (OR, 1.82, P=0.001), DBP (OR, 0.88, P=0.041), and fasting glucose (OR, 0.34, P<0.001) were independent predictors of stroke.ConclusionsSerum HO-1 level is higher in patients with stroke than TIA, but the bilirubin level is lower in patients with stroke than TIA and is an independent predictor of stroke. Further studies are warranted to clarify the underlying link among HO-1, bilirubin and stroke. |
| |
Keywords: | Heme oxygenase-1 (HO-1) stroke bilirubin |
|
|