From the Research Department, Marie Curie Memorial Foundation, The Chart, Oxted, Surrey, England; Neurology Department, Charing Cross Hospital, Fulham Palace Road, London, England
Abstract:
SYNOPSIS Hepatic function as estimated from the plasma kinetics of antipyrine has been determined in 32 migraine patients. A high proportion of patients exhibited abnormal plasma half-life and metabolic clearance rates for this drug. The serum levels of copper and zinc were also estimated in these patients; the ratio copper:zinc was uniformly higher than that of controls.